SPD

SPERMIDINE

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is present as a standalone ligand in 182 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 5 entries

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Chemical Component Summary
Name	SPERMIDINE
Synonyms	N-(2-AMINO-PROPYL)-1,4-DIAMINOBUTANE; PA(34)
Identifiers	N-(3-aminopropyl)butane-1,4-diamine
Formula	C₇ H₁₉ N₃
Molecular Weight	145.246
Type	NON-POLYMER
Isomeric SMILES	C(CCNCCCN)CN
InChI	InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
InChIKey	ATHGHQPFGPMSJY-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	29
Chiral Atom Count	0
Bond Count	28
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB03566
Name	Spermidine
Groups	experimental
Description	Spermidine is a polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures. It is a precursor of spermine.
Synonyms	4-azaoctane-1,8-diamine 1,5,10-triazadecane N-(3-aminopropyl)butane-1,4-diamine 4-azaoctamethylenediamine Spermidine N-(3-Aminopropyl)-1,4-butane-diamine Spermidin
Categories	Amines Biogenic Amines Biogenic Polyamines OCT1 substrates Polyamines
CAS number	124-20-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Beta-1 adrenergic receptor	MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESP...	unknown
Beta-2 adrenergic receptor	MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFG...	unknown
Thioredoxin reductase 1, cytoplasmic	MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTST...	unknown
Gentamicin 3'-acetyltransferase	MLRSSNDVTQQGSRPKTKLGGSSMGIIRTCRLGPDQVKSMRAALDLFGRE...	unknown
Spermidine/putrescine-binding periplasmic protein	MKKWSRHLLAAGALALGMSAAHADDNNTLYFYNWTEYVPPGLLEQFTKET...	unknown
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682