QUS

(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID


Toggle HydrogenToggle Labels

Chemical Component Summary

Name(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID
SynonymsQUISQUALATE
Identifiers(2S)-2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
FormulaC5 H7 N3 O5
Molecular Weight189.126
TypeNON-POLYMER
Isomeric SMILESC([C@@H](C(=O)O)N)N1C(=O)NC(=O)O1
InChIInChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
InChIKeyASNFTDCKZKHJSW-REOHCLBHSA-N

Chemical Details

Formal Charge0
Atom Count20
Chiral Atom Count1
Bond Count20
Aromatic Bond Count5

Drug Info: DrugBank

DrugBank IDDB02999 
NameQuisqualic acid
Groups experimental
DescriptionQuisqualic acid is an agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of _Quisqualis chinensis_.
Synonyms
  • Quisqualate
  • Quisqualic acid
Categories
  • Amino Acids
  • Amino Acids, Peptides, and Proteins
  • Excitatory Amino Acid Agents
  • Excitatory Amino Acid Agonists
  • Neurotransmitter Agents
CAS number52809-07-1

Drug Targets

NameTarget SequencePharmacological ActionActions
Glutamate receptor 2MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQ...unknown
Glutamate receptor ionotropic, kainate 2MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPM...unknown
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL279956
PubChem 6971145, 40539
ChEMBL CHEMBL168279, CHEMBL279956
ChEBI CHEBI:8734