PUY

PUROMYCIN

Find entries where: PUY

is present as a standalone ligand in 5 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 1 entries

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Chemical Component Summary
Name	PUROMYCIN
Identifiers	(2S)-2-amino-N-[(2S,3S,4R,5R)-5-(6-dimethylaminopurin-9-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide
Formula	C₂₂ H₂₉ N₇ O₅
Molecular Weight	471.51
Type	RNA LINKING
Isomeric SMILES	CN(C)c1c2c(ncn1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](Cc4ccc(cc4)OC)N)O
InChI	InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32)/t14-,15+,16+,18+,22+/m0/s1
InChIKey	RXWNCPJZOCPEPQ-NVWDDTSBSA-N

Chemical Details
Formal Charge	0
Atom Count	63
Chiral Atom Count	5
Bond Count	66
Aromatic Bond Count	16

Drug Info: DrugBank

DrugBank ID	DB08437
Name	Puromycin
Groups	experimental
Description	Puromycin is an antibiotic that prevents bacterial protein translation. It is utilized as a selective agent in laboratory cell cultures. Puromycin is toxic to both prokaryotic and eukaryotic cells, resulting in significant cell death at appropriate doses.
Synonyms	puromicina Puromycin
Categories	Acids, Carbocyclic Agents that produce neuromuscular block (indirect) Aminoglycoside Antibacterials Anti-Bacterial Agents Anti-Infective Agents Antimetabolites Antineoplastic Agents Antiparasitic Agents Antiprotozoals Carbohydrates Cinnamates Enzyme Inhibitors Glycosides Heterocyclic Compounds, Fused-Ring Nephrotoxic agents Noxae Nucleic Acids, Nucleotides, and Nucleosides Nucleosides Protein Synthesis Inhibitors Purine Nucleosides Purines Toxic Actions Trypanocidal Agents
CAS number	53-79-2

Drug Targets

Name	Target Sequence	Pharmacological Action
60S ribosomal protein L10-like	MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGG...	unknown
60S ribosomal protein L13a	MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRN...	unknown
60S ribosomal protein L23	MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLN...	unknown
60S ribosomal protein L15	MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARR...	unknown
60S ribosomal protein L19	MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLI...	unknown
60S ribosomal protein L23a	MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPK...	unknown
Probable ribosome biogenesis protein RLP24	MRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVR...	unknown
60S ribosomal protein L26-like 1	MKFNPFVTSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIR...	unknown
60S ribosomal protein L8	MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIH...	unknown
60S ribosomal protein L37	MTKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWS...	unknown
60S ribosomal protein L3	MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYK...	unknown
60S ribosomal protein L11	MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVF...	unknown
Leucyl/phenylalanyl-tRNA--protein transferase	MRLVQLSRHSIAFPSPEGALREPNGLLALGGDLSPARLLMAYQRGIFPWF...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682