Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928.[A262596] It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults.[A262601] Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, hydroxyurea is used sparingly in clinical settings, largely due to lack of knowledge and adherence, the need for therapeutic monitoring, and serious side effects of secondary cancer and birth defects.[A262606]
Synonyms
Hydroxycarbamid
Hydroxycarbamide
Hydrea
Carbamohydroxamic acid
Hydroxycarbamidum
Hydroxyharnstoff
Hydroxyurea
Carbamyl hydroxamate
N-Carbamoylhydroxylamine
Carbamoyl oxime
Carbamohydroximic acid
Oxyurea
Hidroxicarbamida
N-Hydroxyurea
Brand Names
Xromi
Hydrea
Droxia
Apo-hydroxyurea
Riva-hydroxyurea
Mylan-hydroxyurea
Hydroxyurea
Siklos
Indication
Hydroxyurea is indicated to reduce the frequency of painful crises and to reduce the need for blood transfusions in adult and pediatric patients, 2 years of age and older, with sickle cell anemia with recurrent moderate to severe painful crises.[L41150]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
