Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins.[A10367] It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [norethynodrel] and [lynestrenol].[A10367] Norethisterone mimics the actions of endogenous [progesterone], albeit with a greater potency,[A188075] and is used on its own or in combination with estrogen derivatives in a variety of applications including contraception and hormone replacement therapy.[L9527,L10301,L10304,L10307] First derived in 1951 in Mexico City, norethisterone was originally intended for use as a remedy for irregular menstruation and endometriosis, and was not marketed for use as an oral contraceptive until 1962.[L10439]
Norethindrone Acetate and Ethinyl Estradiol and Ferrous Fumarate
Jevantique Lo
Loestrin 24 Fe
Melodetta 24 Fe
Larin 24 Fe
Zeosa
Wera
Brevicon 1/35 28 Tab
Ortho-novum 1/50 Tablets (21 Day)
Ortho 7/7/7 Tablets (28 Day)
Synphasic 28 Tablets
HAILEY Fe 1/20
Errin
Necon 10/11
Norlutate
Cyonanz
Necon 777
Select 1/35 (21-day)
Microgestin
Estradiol / Norethindrone Acetate
LOESTRIN Fe 1/20 28 Day
Emzahh
Norethindrone Acetate and Ethinyl Estradiol
Norethindrone and ethinyl estradiol
Femhrt
Norethindrone
Aygestin
Activelle Ld
Alyacen 7/7/7
Mimvey Lo
Necon 1/35 (28 Day Regimen)
GENERESS Fe
LOESTRIN Fe 1/20
TARINA Fe 1/20
Activelle
MICROGESTIN Fe 1/20
Nora-BE
LOESTRIN Fe 1.5/30
Brevicon 0.5/35 Tablets (28-day Pack)
Briellyn
Ortho 10/11 Tablets (21 Day)
Lyleq
Modicon
ESTROSTEP Fe
Larin Fe 1/20
Norlyda
Nylia 1/35
Cyclafem 7/7/7
Junel 1.5/30
Ortho-novum 10/11
Brevicon 0.5/35 Tablets (21-day Pack)
Synphasic-28 Tablets
Ortho Novum 1/35
Gildess 1/20
Hailey Fe 1.5/30
Nortrel 28 Day
Lomedia 24 Fe
Maeve
Cyclafem 1/35
Lolo
Gildess 1.5/30
Generess
Jinteli
LOESTRIN Fe 1.5/30 28 Day
Norethindrone and ethinyl estradiol and ferrous fumarate
Norinyl
Hailey 24 Fe
Ortho 0.5/35 Tablets (21 Day)
Pirmella 1/35
Necon 777 777
Nortrel 7/7/7 (28 Day Regimen)
Merzee
Gildess 24 Fe
Tulana
Ortho 1/35 Tablets (28 Day)
Norethindrone acetate
Junel Fe 1/20
Tarina 24 Fe
Aurovela 1.5/30
Estalis 250/50 Mcg
Gildess Fe 1/20
Loestrin 21 1/20
Norethindrone and Ethinyl Estradiol, and Ferrous Fumarate
Leena
Lo Minastrin Fe
Norethindrone and Ethinyl Estradiol and Ferrous Fumarate
Micronor Tablets 28-day
Norethindrone Acetate and Ethinyl Estradiol, and Ferrous Fumarate
Sharobel
Taysofy
Pirmella 7/7/7
Micronor
Zenchent FE
Fyavolv
Brevicon 0.5/35 28 Tab
Heather
Indication
Norethisterone is indicated as an oral contraceptive when given as monotherapy[L9527] or in combination with an estrogen component, such as [ethinylestradiol] or [estradiol].[L10313,L10307] In combination with an estrogen component, oral norethisterone is also indicated as a hormone replacement therapy in the treatment of postmenopausal osteoporosis and moderate-to-severe vasomotor symptoms arising from menopause.[L10304] When applied via transdermal patch, the combination of norethisterone and estradiol is indicated for the treatment of hypoestrogenism, vulvovaginal atrophy, and moderate-severe vasomotor symptoms.[L10301] Norethisterone, taken in combination with intramuscular [leuprolide], is also indicated for the symptomatic treatment of endometriosis-related pain.[L10310]
Categories
Adrenal Cortex Hormones
Anti-Gonadotropin-Releasing Hormones
Combination Contraceptives (with Estrogen and derivatives)
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682