MOF

MOMETASONE FUROATE

Find entries where: MOF

is present as a standalone ligand in 3 entries

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Chemical Component Summary
Name	MOMETASONE FUROATE
Identifiers	[(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroethanoyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
Formula	C₂₇ H₃₀ Cl₂ O₆
Molecular Weight	521.429
Type	NON-POLYMER
Isomeric SMILES	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CCl)OC(=O)c5ccco5)C)O)Cl)C
InChI	InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
InChIKey	WOFMFGQZHJDGCX-ZULDAHANSA-N

Chemical Details
Formal Charge	0
Atom Count	65
Chiral Atom Count	8
Bond Count	69
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB14512
Name	Mometasone furoate
Groups	vet_approved investigational approved
Description	Mometasone furoate is a corticosteroid drug that can be used for the treatment of asthma, rhinitis, and certain skin conditions[FDA Label][F4292,F4295]. It has a glucocorticoid receptor binding affinity 22 times stronger than [dexamethasone] and higher than many other corticosteroids as well[A176906]. Mometasone furoate is formulated as a dry powder inhaler, nasal spray, and ointment for its different indications[FDA Label][F4292,F4295].
Synonyms	Mometasone furoate Mometasone furoate monohydrate Mometasone furoate anhydrous
Brand Names	Childrens Nasonex Nasonex Quinosone Zenhale Bemrist Breezhaler Nasal Allergy and Congestion Relief Asmanex Leader Nasal Taro-mometasone Lotion Asmanex Twisthaler Allergy Nasal Momexin Sinuva Teva-mometasone Up and Up Allergy Rugby mometasone furoate nasal Sandoz Mometasone PMS-mometasone Mometacure Elocom Mometasone Furoate Ryaltris Taro-mometasone Ointment Zimbus Breezhaler Topcare Allergy Enerzair Breezhaler Elocon Apo-mometasone Asmanex HFA Taro-mometasone Cream Hyaluronic Acid Sodium Salt 2% / Mometasone Furoate 0.1% / Niacinamide 4% Mometasone Furoate Monohydrate Mometasone Atectura Breezhaler Mosaspray Nasonex Allergy and Congestion Quinixil Dulera
Indication	Inhaled mometasone furoate is indicated for prophylaxis of asthma in patients ≥4 years.[L9560] Applied topically as an ointment, mometasone furoate is indicated for symptomatic treatment of dermatitis and pruritis in patients ≥2 years.[L9590] Mometasone furoate nasal spray is available both over-the-counter (OTC) and by prescription. The OTC nasal spray formulation of mometasone furoate is indicated for the treatment of upper respiratory allergic symptoms (e.g. rhinorrhea, sneezing) in patients ≥2 years of age.[L42300] The prescription formulation is indicated for the treatment of chronic rhinosinusitis with nasal polyps in patients ≥18 year old and for the and prophylaxis of seasonal allergic rhinitis in patients ≥12 years old.[L9563] It is also approved in combination with [olopatadine] for the symptomatic treatment of seasonal allergic rhinitis in patients ≥12 years.[L39845]
Categories	Adrenal Cortex Hormones Adrenals Adrenergics, Inhalants Anti-Allergic Agents Anti-Inflammatory Agents Corticosteroids Corticosteroids, Dermatological Preparations Corticosteroids, Potent (Group III) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors (strong) Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Inducers Cytochrome P-450 CYP3A5 Inducers (strength unknown) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Drugs for Obstructive Airway Diseases Fused-Ring Compounds Glucocorticoids Hyperglycemia-Associated Agents Immunosuppressive Agents Nasal Preparations Pregnadienes Steroids Thyroxine-binding globulin inhibitors
ATC-Code	D07AC13 R03BA07 D07XC03 R01AD09 R03AK09
CAS number	83919-23-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Glucocorticoid receptor	MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAV...	unknown
Progesterone receptor	MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSA...	unknown
Cytochrome P450 2C8	MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate,inducer
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	inducer

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682