MAY

METHYL ARACHIDONYL FLUOROPHOSPHONATE

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as a non-polymer is covalently linked to polymer or other heterogen groups 4 entries

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Chemical Component Summary
Name	METHYL ARACHIDONYL FLUOROPHOSPHONATE
Synonyms	MAFP
Identifiers	(5Z,8Z,11Z,14Z)-1-[fluoro(methoxy)phosphoryl]icosa-5,8,11,14-tetraene
Formula	C₂₁ H₃₆ F O₂ P
Molecular Weight	370.482
Type	NON-POLYMER
Isomeric SMILES	CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC[P@](=O)(OC)F
InChI	InChI=1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-/t25-/m0/s1
InChIKey	KWKZCGMJGHHOKJ-WTIHWRCNSA-N

Chemical Details
Formal Charge	0
Atom Count	61
Chiral Atom Count	1
Bond Count	60
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB02465
Name	Methoxy arachidonyl fluorophosphonate
Groups	experimental
Description	Methoxy arachidonyl fluorophosphonate, commonly referred as MAFP, is an irreversible active site-directed enzyme inhibitor that inhibits nearly all serine hydrolases and serine proteases. It inhibits phospholipase A2 and fatty acid amide hydrolase with special potency, displaying IC50 values in the low-nanomolar range.
Synonyms	MAFP Methoxy arachidonyl fluorophosphonate Methyl arachidonylfluorophosphonate
Categories	Eicosanoids Enzyme Inhibitors Fatty Acids Fatty Acids, Essential Fatty Acids, Unsaturated Lipids Organophosphorus Compounds Phospholipases A, antagonists & inhibitors
CAS number	180509-15-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Fatty-acid amide hydrolase 1	MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRA...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682