LPA

LIPOIC ACID

Find entries where: LPA

is present as a standalone ligand in 8 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 2 entries

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Chemical Component Summary
Name	LIPOIC ACID
Synonyms	5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid
Identifiers	5-[(3R)-1,2-dithiolan-3-yl]pentanoic acid
Formula	C₈ H₁₄ O₂ S₂
Molecular Weight	206.326
Type	NON-POLYMER
Isomeric SMILES	C1CSS[C@@H]1CCCCC(=O)O
InChI	InChI=1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
InChIKey	AGBQKNBQESQNJD-SSDOTTSWSA-N

Chemical Details
Formal Charge	0
Atom Count	26
Chiral Atom Count	1
Bond Count	26
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00166
Name	Lipoic acid
Groups	investigational nutraceutical approved
Description	A vitamin-like antioxidant.
Synonyms	D-thioctic acid (+)-alpha-Lipoic acid Thioctic acid D-form (R)-(+)-lipoic acid R-alpha-lipoic acid α-lipoic acid (R)-lipoic acid alpha-Liponsäure Thioctic acid (R)-6,8-thioctic acid (R)-1,2-dithiolane-3-valeric acid (R)-(+)-Lipoate (R)-1,2-Dithiolane-3-pentanoic acid Alpha lipoic acid R-(+)-thioctic acid alpha-Lipoic acid Lipoic acid
Brand Names	Vita-Rx Diabetic Vitamin Fibrik Dayavite Noxicare Methazel Mebolex Corvita Oveeza Protect Plus SO 60 Folic-K Protect Cardio AF Dyzbac Folica-V Corvite Corvite Free Tru-micin Strovite One Caplets Medi-10 Nicadan
Indication	For nutritional supplementation, also for treating dietary shortage or imbalance.
Categories	Alimentary Tract and Metabolism Antioxidants Biological Factors Coenzymes Compounds used in a research, industrial, or household setting Dietary Supplements Enzymes and Coenzymes Fatty Acids Hypoglycemia-Associated Agents Lipids Micronutrients Protective Agents Sulfur Compounds Supplements Thiophenes Various Alimentary Tract and Metabolism Products Vitamin B Complex Vitamins
ATC-Code	A16AX01
CAS number	1200-22-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Lipoyltransferase 1, mitochondrial	MLIPFSMKNCFQLLCNCQVPAAGFKKTVKNGLILQSISNDVYQNLAVEDW...	unknown
Sodium-dependent multivitamin transporter	MSVGVSTSAPLSPTSGTSVGMSTFSIMDYVVFVLLLVLSLAIGLYHACRG...	unknown
Lipoyl synthase, mitochondrial	MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVS...	unknown
NADPH--cytochrome P450 reductase	MGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEE...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682