KOV

(6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

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is present as a standalone ligand in 1 entries

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Chemical Component Summary
Name	(6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonyms	Cefuroxime
Identifiers	(6R,7R)-3-(aminocarbonyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyimino-ethanoyl]amino]-8-oxidanylidene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Formula	C₁₆ H₁₆ N₄ O₈ S
Molecular Weight	424.385
Type	NON-POLYMER
Isomeric SMILES	CO/N=C(/c1ccco1)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O
InChI	InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9-/t10-,14-/m1/s1
InChIKey	JFPVXVDWJQMJEE-IZRZKJBUSA-N

Chemical Details
Formal Charge	0
Atom Count	45
Chiral Atom Count	2
Bond Count	47
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB01112
Name	Cefuroxime
Groups	approved
Description	Broad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Synonyms	Cefuroximo Cephuroxime Cefuroximum Cefuroxime Cefuroxime axetil Cefuroxime sodium Cefuroxim Cefuroxima (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-furan-2-yl-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Brand Names	Zinacef Inj 750mg/vial Ceftin - Tab 500mg Zinacef Inj 7.5gm/vial Kefurox Kefurox Inj Pws 1.5gm/add-vantage Vial Zinacef Nu-cefuroxime Ceftin Cefuroxime Sodium Cefuroxime Axetil For Oral Suspension Ceftin - Pwr 250mg/sachet Cefuroxime sodium Cefuroxime Axetil Kefurox Inj Pws 750mg/add-vantage Vial Zinacef Inj 1.5gm/vial Novo-cefuroxime Ratio-cefuroxime Ceftin for Oral Suspension-pws 250mg/pck Cefuroxime for Injection, USP Zinacef Injection - Pws Im IV 750mg/vial Cefuroxime axetil Cefuroxime for Injection USP Zinacef Injection - Pws IV 1.5gm/vial Apo-cefuroxime Ceftin Tab 500mg Zinacef Injection - Pws IV 7.5gm/vial Cefuroxime and Dextrose Ceftin Tab 250mg Cefuroxime Orb-cefuroxime Ceftin - Tab 250mg Pro-cefuroxime - 500 Auro-cefuroxime Ceftin Pws 125mg/5ml
Indication	For the treatment of many different types of bacterial infections such as bronchitis, sinusitis, tonsillitis, ear infections, skin infections, gonorrhea, and urinary tract infections.
Categories	Amides Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use beta-Lactams Cephalosporins Heterocyclic Compounds, Fused-Ring Lactams Nephrotoxic agents Ophthalmologicals Second-Generation Cephalosporins Sensory Organs Sulfur Compounds Thiazines
ATC-Code	S01AA27 J01DC02 J01RA03
CAS number	55268-75-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Penicillin-binding protein 1A	MTERKREHKDRKQNKNSPKNQSKVTKFLKWFFIGILLLGITAVTVVGIYV...	unknown	inhibitor
Solute carrier family 15 member 1	MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDN...	unknown	inhibitor
Solute carrier family 15 member 2	MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIV...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682