HSM

HISTAMINE

Find entries where: HSM

is present as a standalone ligand in 34 entries

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Chemical Component Summary
Name	HISTAMINE
Identifiers	2-(1H-imidazol-4-yl)ethanamine
Formula	C₅ H₉ N₃
Molecular Weight	111.145
Type	NON-POLYMER
Isomeric SMILES	c1c(nc[nH]1)CCN
InChI	InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
InChIKey	NTYJJOPFIAHURM-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	17
Chiral Atom Count	0
Bond Count	17
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB05381
Name	Histamine
Groups	investigational approved
Description	A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
Synonyms	Histamine Histamine phosphate beta-aminoethylglyoxaline 1H-Imidazole-4-ethanamine Histamine dihydrochloride beta-aminoethylimidazole 4-imidazoleethylamine 5-imidazoleethylamine 2-(4-imidazolyl)ethylamine
Brand Names	HAVASU HEMP Soothing Pain Relief Rub Australian Dream Back Pain Arthritis Pain Relief Cream Alo Therapeutic Massage Pain Relieving Histamine Phosphate Injection USP Liq Sc Minted Leaf Odorless Pain Relief Positive Skin Test Control-histamine Arthrocare Lotion Raging Kakapo Pain Relieve Histamine DHCl 0.10 Percent and Menthol 2 Percent Alo Therapeutic Massage Ponos Natural Pain Relief REVIVE SCIENCE Natural Hemp Pain Relief Rub Dr. Freds MIRACLE RUB Histamine Phosphate Injection USP, 1mg/ml TerraFreeze Pain Relief MUSCLESHOK Sport Australian Dream Hand and Wrist Pain CVS Arthritis Pain Relief ActivOn Ultra Strength Arthritis Rematex BAKERS BEST Arthritis Pain Relief Cream with Hemp and Lavender PainMD Max Glucosamine Cream EXTRA STRENGTH Positive Skin Test Control - Histamine MUSCLESHOK Back Pain Arthritis Relief Histatrol Pain Relieving Arthritis Walgreens Arthritis Pain Relief Cream Camphomex Royal Labs Hemp Recover Bakers Best Arthritis Pain Relief Ceplene Md Science Cannabigerol Abee Med Mancore Muscle Mend Roll-ON Pain Reliever Australian Dream Pain Relieving Arthritis Australian Dream Carpal Tunnel Pain Simanix Arthritis Pain Relief Histamine Positive Skin Test Control DR. MIKES Ponos Pain Relief Cream Roll-On Midalgan Bakers Best Arthritis Pain Relief with Hemp Seed ROPANA Pain Relief Cream Hand and Wrist Pain Cream MINTED LEAF Odorless Histamine DHCl Pain Relief and Hemp Extract Histamine DHCl 0.10 Percent AMINO ACTIVE Topical Analgesic Cream Md Science Cannabidiol
Indication	Histamine phosphate is indicated as a diagnostic aid for the evaluation of gastric acid secretory function.
Categories	Adjuvants, Immunologic Amines Antineoplastic and Immunomodulating Agents Autacoids Biogenic Amines Biogenic Monoamines Biological Factors Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 Enzyme Inhibitors Diagnostic Agents Ethylamines Gastric Function Histamine Agents Histamine Agonists Imidazoles Inflammation Mediators Neurotransmitter Agents OCT1 substrates OCT2 Inhibitors OCT2 Substrates Other Diagnostics Tests for Gastric Secretion
ATC-Code	L03AX14 V04CG03
CAS number	51-45-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Histamine H1 receptor	MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLY...	unknown	agonist
Histamine H2 receptor	MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLR...	unknown	agonist
Histamine H3 receptor	MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVL...	unknown	agonist
Histamine H4 receptor	MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRS...	unknown	agonist
Synaptic vesicular amine transporter	MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYS...	unknown
Histamine N-methyltransferase	MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDT...	unknown	substrate
Solute carrier family 22 member 2	MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHR...	unknown	substrate,inhibitor
Solute carrier family 22 member 1	MPTVDDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHC...	unknown
Solute carrier family 22 member 3	MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYW...	unknown	inhibitor
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682