HQE

benzene-1,4-diol

Find entries where: HQE

is present as a standalone ligand in 7 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 4 entries

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Chemical Component Summary
Name	benzene-1,4-diol
Identifiers	benzene-1,4-diol
Formula	C₆ H₆ O₂
Molecular Weight	110.111
Type	NON-POLYMER
Isomeric SMILES	c1cc(ccc1O)O
InChI	InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
InChIKey	QIGBRXMKCJKVMJ-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	0
Bond Count	14
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB09526
Name	Hydroquinone
Groups	investigational approved
Description	Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids, or sunscreen. Hydroquinone has come under scrutiny due to several complications associated with its use, including dermal irritation, exogenous onchronosis, and carginogenicity. As a result of these concerns, hydroquinone has been banned in the EU and UK.
Synonyms	p-Hydroquinone 1,4-dihydroxybenzene benzene-1,4-diol p-Benzenediol 1,4-benzenediol p-hydroxyphenol Quinol Hydroquinone 4-Hydroxyphenol
Brand Names	Porcelana Skin Lightening Daytime Protection Hyperpigmentation Treatment Dual Action Skin Lightener Sunbalance Nu-derm Starter Set Normal-dry Skin Transformation System MD Acne Medicated Dark Spot Remover NeoStrata HQ Skin Lightening Melquin 3 Vividly Brilliant Perfecting Unblemish Dermatologist Developed Spot Fading Toner Ambi Fade Oily Skin Topiclear Skin Lightening Accelerated Dark Spot Corrector Glytone Clarifying SunVanish with Sunscreen REVERS Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Travel Size Cicatricure Skin Lightening Hydroquinone 5% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025% Neostrata Hq Plus Lightening Cream Metasol Corrector Light Fade Dark Spots Daytime Treatment Movate Lemon eB5 Age Sport Formula Melpaque HP Obagi-C Rx system C-Therapy Night Skin Lightening with Vitamins C and E Ambi Skincare Normal Skin Fade Skinprint Recover Lightening Complex with 2% Hydroquinone Phaze 13 Light N' Block Pigment Cream Ultra Glow Skin Tone Cream for Oily Skin Othine Skin Bleach Body Fade Creme Maximum Strength Teatrical Pro-Aclarant Skin Lightening Hydroquinone Skin Bleaching Agent Oily Skin MELAMIX Skin Lightener and Blending EB5 Age Spot Treatment gloTriple Action Serum African Formula Skin Lightening ZO Skin Health Pigment Control plus Brightening Creme Hydroquinone plus Vitamin C Palmer's Skin Success Fade Cream-normal Skin Brighten Lightening Clear-N-Smooth SuperMax Esoterica Unscented Fortified W.sun Screen Topiclear Lemon LumaSilk Emulsion Level 03 Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, NeoCeuticals Post Acne Fade Aclaro Hydroquinone Idole Beauty Clear-N-Smooth UltraMax Pharmaskincare Serum Skin Lightening Topiclear Xtra lemon beauty Eldopaque Forte Crm 4% Fade Away Extra Care Nadinola Skin Disc.fade Crm for Dry Skin 2% Black Opal Advance Dual Complex Fade Gel Nu-derm System Normal-dry Skin Transformation Ultra Glow Skin Tone Cream for Normal Skin Pigment African Gold Skin Discoloration Fade Crm 2% AMBI Fade Oily Skin African Formula Black Condition and Enhance System Travel-size Non-surgical Top White Skin Lightening Epiquin Micro Gold Cosmetics Adi Clear Ultraquin 4% Hydroquinone Cream With Sunscreens ZO Skin Health Pigment Control Plus Blending Creme Hydroquinone Pure Valley Miracle Age Spot Skin Lightening Complex Piona Gold Cosmetics Bleach Cream Silver Solaquin Eldoquin Forte SYMBA Skin Lightening Movate Skin Lightening Lemon PLEXADERM Dark Spot Fade Gel Nu-derm Travel Set Normal/dry Skin Transformation System Celazome Fade Shades Lightening Cream w/ Glycolic Acid Proactiv Skin Lightening Lightening HQ Spot Hydroquinone cream Hydroquinone with sunscreens Gold Cosmetics Bleach Cream Forte Hydroquinone 4% / Tretinoin 0.025% Idole Skin Lightening Active 4 Topiclear Conditioning Gel Restoration Serum Epione Esoterica Daytime with Moisturizers and Sunscreen Creme Blanchissante - Crm 2% Triderma Lustra Drula Fade Cream Medium-medicated Aclaro PD Hydroquinone Topiclear Paris Fair and White Daily Fade Maximum Strength SPF15 Esoterica Scented-fortified With Sunscreen New York Fair and Lovely Hydroquinone 8%. Advanced Lightning Advanced Skin Lightening Serum Borba Age Defying Skin Lightening Spot Treatment Esoterica Sunscreen Fade Cream Idole Intense BEST Age Spot Remover SLMD Skincare by Sandra Lee, M.D. - Dark Spot Fix Meaningful Beauty Dark Spot Correcting Treatment Clairissime Clear Complexion Lotion Eldopaque Crm 2% Hydroquinone Time Release Black Opal Advanced Dual Phase Fade Creme Obagi Porcelana Night Skin Lightening Nu-derm System Normal-oily Skin Transformation Trial Teatrical Skin Lightening Skin Lightener Ultra Glow Skin Tone Cream Oily Skin Aloe Vera Clear-N-Smooth Ultimate Ultra Glow Skin Tone Cream Dry Skin Aloe Vera Esoterica Daytime with Sunscreen Caro Light Porcelana Skin Lightening Nighttime Hydration Fading Fluid Skinprint ClearTone with 8% Hydroquinone Seequin 4 Hydroquinone 4% Seequin 2 Hydroquinone 6% /tretinoin 0.05% Alumier MD Lightening Lumipearl Dark Mark Corrector Porcelana Medicated Fade Cream - Orig. Fmla Recover Lightening Complex with 4% Hydroquinone AGELESS Total Skin Bleaching Serum Ultraplus Skin Lightening Cream - 2% Topiclear Paris Beauty Eldoquin Light The Way Erfa Hydroquinone Alphaquin HP Ultra Glow Fade Exence White Unblemish Regimen for Acne and Post Acne Marks Dolly Intense Lightening Top White Exuviance Intense Lightening Complex Lustra-AF Olivia Quido Skincare Blemish Eraser Sunvanish Vantex Skin Bleaching Crm W Sunscreen 2% Solaquin Forte Ambi Extra Skin Discoloration Fade Cream Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% ZO MEDICAL MELAMIN-C Skin Bleaching and Correcting with Vitamin C Hydroquinone Dr. Lightening Ultra-Potent Facial OLIVIA QUIDO FIRM and FADE II ELASTIDERM DECOLLETAGE SKIN LIGHTENING COMPLEX Chest and Neck NU-DERM system NORMAL-oily SKIN TRANSFORMATION TRIAL Dr. Throwers Skin Lightening Moisturizing ZO Skin Health Pigment Control Program Plus Hydroquinone Dermisa Skin Fade Vitamin C infused Obagi Medical - Nu-Derm System - Normal to Dry - Skin Transformation Kit Balancer Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05% Movate Carrot Skin Lightener Skinprint 3D Clear Peel Hydrocortisone 0.5% / Hydroquinone 6% Artra Skin Tone for Oily Skin Double White Sledgehammer Meditowel Illuminating Skin Brightening Spotfade Dark Spot Wand OBAGI-C RX system NORMAL-oily SKIN INTERVENTION Rejuvaderm medispa fading Idole Black 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Rodan & Fields Proactiv Solution: Skin Lightening Lotion Fade Dark Spots Nighttime Treatment Obagi Nu-Derm Nadinola Skin FadeExtra Clarite 4 Skin Lightening Rodan Fields Nu-derm Starter Set Normal-oily Skin Transformation System Hqra-otc ZO Skin Health Multi-Therapy Hydroquinone System Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Porcelana 24 Hour Skin Lightening Hydroquinone 8% / Tretinoin 0.025%. OLIVIA QUIDO FIRM and FADE I Artra Skin Tone for Normal Skin Movate Skin Lightening Nuderm Sunfader Hot Movate Divine Derrier Skin Bleaching cream Obagi Medical - Nu-Derm System - Normal to Dry - Skin Transformation Trial Kit Clear Essence Medicated Fade Cream Dark Spot Lightening Cream Medisilke Night Idole Carrot Idole Lemon CONDITION AND ENHANCE BLENDER Skin Lightener and Blending Obagi Nu-Derm Sunfader Ambi Fade Normal Skin Banishing Cream Pharmaskincare Parfait Lightening Serum Zarina Skin Lightening Cream With Sunscreening Filter Palmer's Skin Success Fade Cream-for Dry Skn Obagi - C 141055 Hydroquinone 6% Clear-N-Smooth PLUS NU-DERM SUNFADER Skin Lightener with Sunscreen (SPF 15) PABA FREE Lustra AF Dermablend Chromatone Fade Cream With Sunscreen Even Tone Night Treatment I-max Lightening L Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Hydroquinone 6% Body Merry Lightening and Whitening Cream Idole Natural Organic Multi Complex Fade Medicated Fade Creme with Sunscreen SH18 Caviar Beauty Miracle Fade Ultra Glow Skin Tone Cream Normal Skin Aloe Vera Glytone Dark Spot Corrector Black and White Skin Bleach Vivant True Tone Forte Idole Natural Organic Skin Lightening AMBI Skincare Oily Skin Fade Skin Lightening Cream NU-DERM BLENDER Skin Lightener and Blending Derma Lightening Seequin 4 Ids Glytone Clarifying Palmer's Skin Success Fade Cream-for Oily Sk Crusader Ultra Skin Lightening Ultra-Potent Brightening Serum Vivant True Tone MELAMIN Skin Bleaching and Correcting Hydroquinone NU-DERM system NORMAL-DRY SKIN TRANSFORMATION TRIAL Hydroquinone 8% / Tretinoin 0.025% Porcelana Day Skin Lightening SH18 Skin Lightening Rodan and Fields Skin Lightening Treatment Glytone Skin Lightening Nadinola Skin Fade for Dry Skin MELAMIN Skin Bleaching and Correcting CONDITION AND ENHANCE CLEAR Skin Bleaching and Corrector Esoterica Regular Cream EpiQuin Micro Nu-derm System Normal-oily Skin Transformation Advanced Dual Complex Fade Maximum Strength Plus 141067 Hydroquinone 8% Corrector 4 Drula Fade Cream Normal-medicated 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Obagi-C Rx System Normal-dry Skin Intervention Neova Complex HQ Plus Skin Lightening Accelerator Pack Clear Essence Skin Lightening Gel SH 18 Whitening Gold Cosmetics Bleach Cream Olivia Quido Blemish Eraser Dermaclair Skin Lightening Esoterica Facial Cream OBAGI-C Rx system C-CLARIFYING SERUM NORMAL TO oily SKIN LIGHTENING SERUM WITH VITAMIN C Pa Plus Advanced Dark Spot Correcting Serum OBAGI-C RX System NORMAL-DRY SKIN INTERVENTION Differin Dark Spot Correcting Serum Topiclear Xtra beauty Skin Lightening Treatment Metasol Skin Lightening Continuum Unifying Lotion I NU-DERM CLEAR Skin Bleaching and Corrector Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05% Neostrata Canada Hq Plus Cream Hydroquinone 4% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025% Jouvence Crm 2% Condition and Enhance System Travel-size Surgical Topiclear Cocoa Butter Enlighten Me Glytone skin bleaching fading eB5 Age Spot Formula Esoterica Nighttime with Moisturizers Condition and Enhance System Full-size Non-surgical SH18 Ultra Harmonie Carrot Beauty Skinprint ClearTone with 2% Hydroquinone Dermisa Skin Fade Zo Medical Zo Multi-therapy Hydroquinone System Artra Skin Tone for Dry Skin Dermablend Advanced Fade Cream With Sunscreen and Moisturizing Aha Skin Beautifying Milk Viquin Forte With Moisturizing Aha - Crm Unblemish Essential Fade Complex 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Clear Essence Advance Complex Fade Gel Dermisa Skin Fade Cream Esoterica Unscented Superlightener Proactiv Advanced Dark Spot Correcting Serum Continuum Unifying Lotion II Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% Nadinola Skin Disc.fade Crm for Oily Skin 2% Glytone SunVanish Skin Lightening Hydro-Q Nadinola Skin Fade for Oily Skin HQ Plus Brightening Cream VI Derm Melquin Hp Porcelana Medicated Fade Crm Sunscreen Fmla Glyquin Xm Advanced Skin Lightening Cream ZO Skin Health Pigment Control Creme Hydroquinone PCA Skin Intensive Pigment Eraser Clear-N-Smooth Super-Ultimate Scarlight MD Activator Light Hydroquinone Skin Bleaching Agent Normal Skin Crusader Skin Lightening Dr. Throwers Pbc No. 1 Perrigo Hydroquinone with sunscreens Drula Fade Cream Extra-medicated Hydroquinone OBAGI C RX system C CLARIFYING SERUM 141011 Hydroquinone 6% Ultra Glow Fade with Aloe Vera Cenovia Nadinola Skin Discoloration Fade Cream-S.C.f LumaSilk Emulsion Level 02 Clear Action Topiclear Carrot Nova Complex HQ Proactiv Solution Dark Spot Corrector Total White Brightening Image MD Lightening Rx Sh18 Obagi-C Rx System Normal-oily Skin Intervention NEXT GENERATION Correct Brightening Serum Obagi Protocols Clear Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Nadinola Skin Fade for Normal Skin Clear-N-Smooth Precious Beauty Skin Lightening Drula Fade Cream Superforte Medicated Tri-luma Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Nu-derm System Normal-dry Skin Transformation Trial Hydroquinone 6% / Tretinoin 0.05% / Triamcinolone 0.025% Bright Malika and Khadija Brightening Spot Treatment 141010 Hydroquinone 4% I-max Lightening 5 REVERSE Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Corrector 2 NU-DERM System NORMAL-Oily SKIN TRANSFORMATION 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Hydroquinone 8% Clear Essence Skin Lightening Milk 141030 Hydroquinone 8% AMBI Fade Normal Skin Topiclear Cocoa Butter beauty Hqla African Formula Carrot Lightener Hyaluronic Acid Sodium Salt 1% / Hydroquinone 6% Nuquin Hp
Indication	Hydroquinone is used as an OTC topical lightening agent for disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots and freckles.
Categories	Antioxidants Benzene Derivatives Biological Factors Compounds used in a research, industrial, or household setting Depigmenting Agents Dermatologicals Melanin Synthesis Inhibitor Melanin Synthesis Inhibitors Mutagens Noxae Phenols Protective Agents Radiation-Protective Agents Toxic Actions
ATC-Code	D11AX11
CAS number	123-31-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Tyrosinase	MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLS...	unknown	inhibitor
Cysteinyl leukotriene receptor 1	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIK...	unknown	activator
Lysosomal alpha-glucosidase	MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLE...	unknown	product of
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL537
PubChem	785
ChEMBL	CHEMBL537
ChEBI	CHEBI:17594
CCDC/CSD	BATRET, CPFEHQ, CIRWEG, AXILUQ, EBILUX, BOKHUG, CEFDOG, COHWIF01, CISCOW, CAKZEV, DOMBEN, BIRQUO, EDAYUG, COZZIB, EDAYEQ, BAVKOA, CABWAD, COHWIF03, ABORAM, COZZOH, BAMZUN01, ACESIL, BAMZUN, AVEKER, EBIMEI, COHWIF02, BUSPAG, BZMETD, EKESIY04, EKESIY05, DIZCEV, DAMPOZ, DAMPOZ01, EKESIY01, EKESIY02, BAMZUN02, EKESIY03, EKESIY06, EKESAQ02, EKESAQ01, ABOQUF, BACRAB, CIPLES, CARWUP, BAMZUN03, COHWIF, CARWUP02, CARWUP01, AVEKIY
COD	2100228, 2100231, 2100714, 2100715, 2100716, 2100717, 2211791, 2103388, 2204577

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.

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HQE

benzene-1,4-diol

Chemical Component Summary

Chemical Details

Drug Info: DrugBank

Drug Targets

Related Resource References