HLZ

1-hydrazinophthalazine

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is present as a standalone ligand in 1 entries

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Chemical Component Summary
Name	1-hydrazinophthalazine
Synonyms	Hydralazine; phthalazin-1-ylhydrazine
Identifiers	phthalazin-1-ylhydrazine
Formula	C₈ H₈ N₄
Molecular Weight	160.176
Type	NON-POLYMER
Isomeric SMILES	c1ccc2c(c1)cnnc2NN
InChI	InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)
InChIKey	RPTUSVTUFVMDQK-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	20
Chiral Atom Count	0
Bond Count	21
Aromatic Bond Count	11

Drug Info: DrugBank

DrugBank ID	DB01275
Name	Hydralazine
Groups	approved
Description	Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed.[A186841] Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment of heart failure.[A186820,L8782,L8785] Hydralazine is no longer a first line therapy for these indications since the development of newer antihypertensive medications.[T691] Hydralazine hydrochloride was FDA approved on 15 January 1953.[L8779]
Synonyms	Hydralazin Hydrazone 1(2H)-phthalazinone 6-Hydralazine Hypophthalin (2H)-Phthalazinone hydrazone Hidralazina Phthalazin-1-ylhydrazine Hydralazine (1Z)-1(2H)-Phthalazinone hydrazone 1-Hydrazinophthalazine Hydralazinum 1-Phthalazinylhydrazine Hydrallazine Idralazina Hydrazinophthalazine Hydralazine hydrochloride
Brand Names	Isosorbide dinitrate and hydralazine hydrochloride hydrALAZINE Hydrochloride PMS-hydralazine Asn-hydralazine Hydralazine-50 Tab Novo-hylazin Tab 25mg Apo-hydralazine Novo-hylazin Tab 10mg USP Nu-hydral Tab 10mg Jamp-hydralazine Ser-Ap-Es Apresoline hydrochloride HydrALAZINE hydrochloride BiDil Nu-hydral Tab 25mg Apresoline Tablets, 50mg Hydralazine Hydralazine HCl and Hydrochlorothiazide Novo-hylazin Tab 50mg HydrALAZINE Hydrochloride Hydralazine-10 Tab 10mg Hydralazine Hydrochloride Injection, USP Mint-hydralazine Apresoline Tablets, 10mg Isosorbide Dinitrate and Hydralazine Hydrochloride Hydralazine Hydrochloride Apresoline Tablets, 25mg Hydralazine Hydrochloride Injection Hydralazine-25 Tab Hydralazine Hydrocloride Apresoline Hydralazine HCl Ser-AP-ES Tab Nu-hydral Tab 50 mg
Indication	Hydralazine is indicated alone or adjunct to standard therapy to treat essential hypertension.[L8782] A combination product with isosorbide dinitrate is indicated as an adjunct therapy in the treatment of heart failure.[L8785]
Categories	Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Arteriolar Smooth Muscle, Agents Acting On Arteriolar Vasodilation Arteriolar Vasodilator Cardiovascular Agents Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Direct Vasodilators Drugs that are Mainly Renally Excreted Hydrazinophthalazine Derivatives Hydrazinophthalazine Derivatives and Diuretics Hypotensive Agents Phthalazines Pyridazines Vasodilating Agents
ATC-Code	C02DB02 C02LG02
CAS number	86-54-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Membrane primary amine oxidase	MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQP...	unknown	inhibitor
Hypoxia-inducible factor 1-alpha	MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNV...	unknown	inducer
Prolyl 4-hydroxylase subunit alpha-1	MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEE...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	inhibitor
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682