GMP

GUANOSINE

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is present as a standalone ligand in 42 entries

is present in a polymer sequence 7 entries

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Chemical Component Summary
Name	GUANOSINE
Identifiers	2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
Formula	C₁₀ H₁₃ N₅ O₅
Molecular Weight	283.241
Type	NON-POLYMER
Isomeric SMILES	c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O)N=C(NC2=O)N
InChI	InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
InChIKey	NYHBQMYGNKIUIF-UUOKFMHZSA-N

Chemical Details
Formal Charge	0
Atom Count	33
Chiral Atom Count	4
Bond Count	35
Aromatic Bond Count	5

Drug Info: DrugBank

DrugBank ID	DB02857
Name	Guanosine
Groups	experimental investigational
Description	Guanosine is a nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become GMP (guanosine monophosphate), cGMP (cyclic guanosine monophosphate), GDP (guanosine diphosphate) and GTP (guanosine triphosphate) which are factors in signal transduction pathways.
Synonyms	2-amino-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one Guanosine 9-β-D-ribofuranosyl-guanine Guanine riboside Guanosina 2(3H)-imino-9-β-D-ribofuranosyl-9H-purin-6(1H)-one Guanosin Guo Guanine-9-β-D-ribofuranoside
Categories	Heterocyclic Compounds, Fused-Ring Nucleic Acids, Nucleotides, and Nucleosides Nucleosides Purine Nucleosides Purines Ribonucleosides
CAS number	118-00-3

Drug Targets

Name	Target Sequence	Pharmacological Action
DNA polymerase	MKEFYLTVEQIGDSIFERYIDSNGRERTREVEYKPSLFAHCPESQATKYF...	unknown
Purine nucleoside phosphorylase	MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDY...	unknown
Purine nucleoside phosphorylase	MSPIHVRAHPGDVAERVLLPGDPGRAEWIAKTFLQNPRRYNDHRGLWGYT...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682