GM6

3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE

Find entries where: GM6

is present as a standalone ligand in 6 entries

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Chemical Component Summary
Name	3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE
Synonyms	GM6001
Identifiers	(2R)-N'-hydroxy-N-[(2S)-3-(1H-indol-3-yl)-1-methylamino-1-oxo-propan-2-yl]-2-(2-methylpropyl)butanediamide
Formula	C₂₀ H₂₈ N₄ O₄
Molecular Weight	388.461
Type	NON-POLYMER
Isomeric SMILES	CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)NC
InChI	InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1
InChIKey	NITYDPDXAAFEIT-DYVFJYSZSA-N

Chemical Details
Formal Charge	0
Atom Count	56
Chiral Atom Count	2
Bond Count	57
Aromatic Bond Count	10

Drug Info: DrugBank

DrugBank ID	DB02255
Name	Ilomastat
Groups	experimental
Description	Ilomastat is a broad-spectrum matrix metalloproteinase inhibitor.
Synonyms	(R)-N(SUP 1)-HYDROXY-N-((S)-2-INDOL-3-YL-1-(METHYLCARBAMOYL)ETHYL)-2-ISOBUTYLSUCCINAMIDE (S-(R,S))-N(SUP 4)-HYDROXY-N(SUP 1)-(1H-INDOL-3-YLMETHYL)-2-(METHYLAMINO)-2-OXOETHYL)-2-(2-METHYLOPROPYL)BUTANEDIAMIDE Ilomastat
Categories	Amines Amino Acids, Peptides, and Proteins Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Hydroxy Acids Hydroxylamines Matrix Metalloproteinase Inhibitors Oligopeptides Peptides Protease Inhibitors
CAS number	142880-36-2

Drug Targets

Name	Target Sequence	Pharmacological Action
Disintegrin and metalloproteinase domain-containing protein 28	MLQGLLPVSLLLSVAVSAIKELPGVKKYEVVYPIRLHPLHKREAKEPEQQ...	unknown
Aggrecan core protein	MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIP...	unknown
Lethal factor	MNIKKEFIKVISMSCLVTAITLSGPVFIPLVQGAGGHGDVGMHVKEKEKN...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682