Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993.[L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain.[A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism making it unlikely to participate in pharmacokinetic drug interactions.[A186143,A185981,L8717]. It is structurally and functionally related to another GABA derivative, [pregabalin].
Synonyms
Gabapentino
Gabapentin
1-(Aminomethyl)cyclohexaneacetic acid
Gabapentine
Gabapentinum
Gabapentina
Brand Names
Mint-gabapentin
Prilopentin -II
Gln-gabapentin
Bci Gabapentin
Gabapal
Innoprax-5
Jamp-gabapentin
Gd-gabapentin
Jamp-gabapentin Tablets
Apo-gabapentin Tablets
Lipritin II
PHL-gabapentin
ACTIVE-PAC with Gabapentin
Prilopentin
Pro-gabapentin
Mylan-gabapentin
Neurontin
Gaba 300-EZS
Dom-gabapentin
Taro-gabapentin
Dipentocaine Topical Cream Compounding Kit
Van-gabapentin
Fanatrex
Ran-gabapentin
Teva-gabapentin
Ratio-gabapentin
Gabapentin Kit
Lido GB-300
Auro-gabapentin Tablets
Gralise
Pendo-gabapentin
Ipg-gabapentin
Bio-gabapentin
Mar-gabapentin
Gapeam Budibac
Sig-gabapentin
Cyclo/Gaba 10/300 Pack
Gabapentin
Jamp Gabapentin Capsules
Mar-gabapentin Tabs
Act Gabapentin
Lipritin
GPL Pak
Lidotin
Gralise Starter Pack
Gabapentin Capsules
Auro-gabapentin
Ntp-gabapentin
Therapentin-90
Gabapentin Capsules USP
Riva-gabapentin
PMS-gabapentin
SmartRx Gaba-V Kit
Topical Nerve Pain
Pentican
Ag-gabapentin
Therapentin-60
SmartRx Gaba Kit
Apo-gabapentin
Nu-gabapentin Capsules
Gabapentin Tablets USP
Gabacaine
Priva-gabapentin
Indication
In the United States, gabapentin is officially indicated for the treatment of postherpetic neuralgia in adults and for the adjunctive treatment of partial-onset seizures, with or without secondary generalization, in patients 3 years of age and older.[L8717] In Europe, gabapentin is indicated for adjunctive therapy in the treatment of partial-onset seizures, with or without secondary generalization, in patients 6 years of age and older and as monotherapy in patients 12 years of age and older. It is also used in adults for the treatment of various types of peripheral neuropathic pain, such as painful diabetic neuropathy.[L8732]
Categories
Acids, Acyclic
Acids, Carbocyclic
Amines
Amino Acids
Amino Acids, Peptides, and Proteins
Aminobutyrates
Analgesics
Anti-epileptic Agent
Anticonvulsants
Butyrates
Central Nervous System Agents
Central Nervous System Depressants
Cyclohexanecarboxylic Acids
Cyclohexanes
Cycloparaffins
Decreased Central Nervous System Disorganized Electrical Activity
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682