FOK

FORSKOLIN

Find entries where: FOK

is present as a standalone ligand in 16 entries

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Chemical Component Summary
Name	FORSKOLIN
Identifiers	[(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] ethanoate
Formula	C₂₂ H₃₄ O₇
Molecular Weight	410.501
Type	NON-POLYMER
Isomeric SMILES	CC(=O)O[C@H]1[C@H]([C@H]2C(CC[C@@H]([C@@]2([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O)(C)C)O
InChI	InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
InChIKey	OHCQJHSOBUTRHG-KGGHGJDLSA-N

Chemical Details
Formal Charge	0
Atom Count	63
Chiral Atom Count	8
Bond Count	65
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB02587
Name	Colforsin
Groups	experimental investigational
Description	Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
Synonyms	colforsinum 7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one Colforsin Coleonolk Forskolin colforsina colforsine
Categories	Adjuvants, Immunologic Anti-Asthmatic Agents Autonomic Agents Bronchodilator Agents Cardiotonic Agents Cardiovascular Agents Compounds used in a research, industrial, or household setting Diterpenes Immunologic Factors P-glycoprotein inhibitors Peripheral Nervous System Agents Protective Agents Respiratory System Agents Terpenes Vasodilating Agents
CAS number	66575-29-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Adenylate cyclase type 2	MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFL...	unknown
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGE...	unknown
Adenylate cyclase type 5	MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSA...	unknown
Cystic fibrosis transmembrane conductance regulator	MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLS...	unknown	inhibitor
Adenylate cyclase	MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFR...	unknown	activator
Calcium-activated potassium channel	MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSS...	unknown	activator
CREB-binding protein	MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGE...	unknown	activator
Extracellular signal-regulated kinase (ERK)	MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVR...	unknown	activator
Mucin-2	MGLPLARLAAVCLALSLAGGSELQTEGRTRYHGRNVCSTWGNFHYKTFDG...	unknown	activator
Plasminogen activator inhibitor 1	MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQAS...	unknown	inhibitor
P-glycoprotein 1	MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLY...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682