EV1

1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE

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is present as a standalone ligand in 5 entries

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Chemical Component Summary
Name	1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE
Synonyms	Papaverine
Identifiers	1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinoline
Formula	C₂₀ H₂₁ N O₄
Molecular Weight	339.385
Type	NON-POLYMER
Isomeric SMILES	COc1ccc(cc1OC)Cc2c3cc(c(cc3ccn2)OC)OC
InChI	InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3
InChIKey	XQYZDYMELSJDRZ-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	46
Chiral Atom Count	0
Bond Count	48
Aromatic Bond Count	17

Drug Info: DrugBank

DrugBank ID	DB01113
Name	Papaverine
Groups	investigational approved
Description	An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Synonyms	Papaverine Papaverine codecarboxylate Papaverine hydrochloride Papaverine sulfate Papaverina
Brand Names	Papaverine Hydrochloride Papaverine Hydrochloride Injection USP
Indication	For the treatment of impotence and vasospasms.
Categories	Alimentary Tract and Metabolism Alkaloids Benzylisoquinolines Cardiovascular Agents Drugs for Functional Gastrointestinal Disorders Drugs Used in Erectile Dysfunction Enzyme Inhibitors Genito Urinary System and Sex Hormones Genitourinary Agents Heterocyclic Compounds, Fused-Ring Hypotensive Agents Isoquinolines Miscellaneous Vasodilatating Agents Moderate Risk QTc-Prolonging Agents Opiate Alkaloids Papaverine and Derivatives Phosphodiesterase Inhibitors QTc Prolonging Agents Urological Agents Urologicals Vasodilating Agents
ATC-Code	G04BE02 A03AD01 G04BE52
CAS number	58-74-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNL...	unknown	inhibitor
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	MRIEERKSQHLTGLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK...	unknown	inhibitor
Phosphodiesterase enzymes	MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGE...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682