EPA

5,8,11,14,17-EICOSAPENTAENOIC ACID

Find entries where: EPA

is present as a standalone ligand in 8 entries

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Chemical Component Summary
Name	5,8,11,14,17-EICOSAPENTAENOIC ACID
Identifiers	(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid
Formula	C₂₀ H₃₀ O₂
Molecular Weight	302.451
Type	NON-POLYMER
Isomeric SMILES	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)O
InChI	InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
InChIKey	JAZBEHYOTPTENJ-JLNKQSITSA-N

Chemical Details
Formal Charge	0
Atom Count	52
Chiral Atom Count	0
Bond Count	51
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00159
Name	Icosapent
Groups	approved nutraceutical
Description	Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Synonyms	all-cis-5,8,11,14,17-icosapentaenoic acid Icosapent cis-5,8,11,14,17-EPA Icosapentum 5,8,11,14,17-eicosapentaenoic acid Eicosapentaenoic acid cis-5,8,11,14,17-eicosapentaenoic acid Icosapentaenoic acid Timnodonic acid Icosapento (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid all-cis-icosa-5,8,11,14,17-pentaenoic acid (all-Z)-5,8,11,14,17-eicosapentaenoic acid 5,8,11,14,17-Icosapentaenoic acid (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid cis-delta(5,8,11,14,17)-Eicosapentaenoic acid EPA all-cis-5,8,11,14,17-eicosapentaenoic acid (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoate Icosapent sodium
Brand Names	Melittin Joint Soothing Ge Premium Omega 3 Gel UltimateCare ONE NF Oveeza NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Se-Tan DHA CitraNatal DHA Tricare Prenatal Twist-off DHA Soft Quick Dissolve Virt-C DHA Herbalifeline natelle COMPLETE PNV-Omega Omega-3 Iq Childrens Chewable Animi-3 with Vitamin D CitraNatal Essence Natelle One Tricare Prenatal 2-part Daily Prenatal Vitamin System Cavan One Vp-CH-pnv Virt-PN Plus TriStart DHA Reliven Virt-Bal DHA Plus A2A Omega-3 WestGel DHA CitraNatal Assure Prenate Essential Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Dothelle DHA TL-Care DHA Gesticare DHA A2A Omega 3 Taliva Se-Plete DHA VITAFOL Gummies Animi-3 Vp-pnv-dha WesCap-C-DHA Tricare Prenatal DHA One Rx Multivitamin Docosavit Folcaps Care One Nutri-Tab OB plus DHA Tricare Prenatal DHA One BP Vit 3 Protect Cardio AF Tricare Prenatal DHA One With Folate Taliment NESTABS ABC Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Ultra Omega 3 Virt-Care One Zatean-Pn Plus Folcaps Omega-3 Super Omega 3
Indication	EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.
Categories	Agents causing hyperkalemia Agents that produce hypertension Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Dietary Fats Dietary Fats, Unsaturated Dietary Supplements Eicosanoids Fats Fatty Acids Fatty Acids, Omega-3 Fatty Acids, Unsaturated Fish Oils Hypolipidemic Agents Lipids Nephrotoxic agents Non COX-2 selective NSAIDS Oils Supplements
CAS number	10417-94-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inhibitor
Prostaglandin G/H synthase 1	MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFG...	unknown	inhibitor
Peroxisome proliferator-activated receptor gamma	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL...	unknown	agonist,regulator
Peroxisome proliferator-activated receptor delta	MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSS...	unknown	agonist
Free fatty acid receptor 1	MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGC...	unknown	agonist
Sodium/calcium exchanger 1	MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECT...	unknown	inhibitor
Fatty acid-binding protein, brain	MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKV...	unknown	agonist
Fatty acid desaturase 1	MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTR...	unknown	agonist
Long-chain-fatty-acid--CoA ligase 4	MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKP...	unknown	inducer
Transient receptor potential cation channel subfamily V member 1	MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLF...	unknown	inducer
Peroxisome proliferator-activated receptor alpha	MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFG...	unknown
Arachidonate 5-lipoxygenase	MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGA...	unknown	substrate
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682