EBI

1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-proli namide

Find entries where: EBI

is present as a standalone ligand in 1 entries

Find related ligands:

Chemical Component Summary
Name	1-{4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methyl-L-proli namide
Synonyms	BMS-754807
Identifiers	(2S)-1-[4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoropyridin-3-yl)-2-methyl-pyrrolidine-2-carboxamide
Formula	C₂₃ H₂₄ F N₉ O
Molecular Weight	461.495
Type	NON-POLYMER
Isomeric SMILES	C[C@]1(CCCN1c2nc(c3cccn3n2)Nc4cc(n[nH]4)C5CC5)C(=O)Nc6ccc(nc6)F
InChI	InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1
InChIKey	LQVXSNNAFNGRAH-QHCPKHFHSA-N

Chemical Details
Formal Charge	0
Atom Count	58
Chiral Atom Count	1
Bond Count	63
Aromatic Bond Count	21

Drug Info: DrugBank

DrugBank ID	DB15399
Name	BMS-754807
Groups	investigational
Description	BMS-754807 is under investigation in clinical trial NCT00908024 (Combination Study of BMS-754807 and Erbitux® in Subjects With Advanced or Metastatic Solid Tumors).
Synonyms	BMS-754807
CAS number	1001350-96-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Insulin-like growth factor 1 receptor	MKSGSGGGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLE...	unknown	inhibitor
Insulin receptor	MATGGRRGAAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHEL...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682