DHF

DIHYDROFOLIC ACID

Find entries where: DHF

is present as a standalone ligand in 17 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 1 entries

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Chemical Component Summary
Name	DIHYDROFOLIC ACID
Identifiers	(2S)-2-[[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]phenyl]carbonylamino]pentanedioic acid
Formula	C₁₉ H₂₁ N₇ O₆
Molecular Weight	443.413
Type	NON-POLYMER
Isomeric SMILES	c1cc(ccc1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=NC3=C(NC2)NC(=NC3=O)N
InChI	InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
InChIKey	OZRNSSUDZOLUSN-LBPRGKRZSA-N

Chemical Details
Formal Charge	0
Atom Count	53
Chiral Atom Count	1
Bond Count	55
Aromatic Bond Count	12

Drug Info: DrugBank

DrugBank ID	DB02015
Name	Dihydrofolic Acid
Groups	experimental
Synonyms	Dihydrofolic Acid
Brand Names	Biopar delta-FORTE EnLyte Extra-LN
CAS number	4033-27-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Dihydrofolate reductase	MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESI...	unknown
Putative pteridine reductase 2	MNETSHEASECPAAIITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQ...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682