A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) The FDA withdrew its approval for the use of all oral and parenteral drug products containing 25 milligrams or more of diethylstilbestrol per unit dose.[L43942]
Synonyms
α,α'-diethyl-(E)-4,4'-stilbenediol
trans-Diethylstilbestrol
Dietilestilbestrol
Diethylstilbestrol diphosphate
(E)-3,4-bis(4-hydroxyphenyl)-3-hexene
Diethylstilbestrolum
Diethylstilbestrol diphosphate sodium
trans-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol
Diethylstilbestrol
DES
Diéthylstilbestrol
Stilboestrol
(E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol
trans-Diethylstilboesterol
4,4'-dihydroxy-α,β-diethylstilbene
trans-Diethylstilbesterol
Brand Names
Honvol Ampoules 250mg
Stilbestrol Tab 1mg
Stilbestrol 0.5mg Tablet
Stilbestrol Tablets 1.0 mg
Stilbestrol Tablets 0.5 mg
Stilboestrol Tab 0.5mg
Stilbestrol 1.0mg Tablet
Stilbestrol Tablets 0.1 mg
Honvol Tablets 100mg
Stilboestrol Tab 0.1mg
Indication
Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery.
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
