Chemical Component Summary

Name{3-[4-(2-AMINO-2-CARBOXY-ETHYL)-1H-IMIDAZOL-2-YL]-1-CARBAMOYL-PROPYL}-TRIMETHYL-AMMONIUM
SynonymsDIPHTHAMIDE; 2-(3-CARBOXYAMIDO-3-(TRIMETHYLAMMONIO)PROPYL)HISTIDINE
Identifiers[(2R)-1-amino-4-[4-[(2S)-2-amino-3-hydroxy-3-oxo-propyl]-1H-imidazol-2-yl]-1-oxo-butan-2-yl]-trimethyl-azanium
FormulaC13 H24 N5 O3
Molecular Weight298.361
TypeL-PEPTIDE LINKING
Isomeric SMILESC[N+](C)(C)[C@H](CCc1[nH]cc(n1)C[C@@H](C(=O)O)N)C(=O)N
InChIInChI=1S/C13H23N5O3/c1-18(2,3)10(12(15)19)4-5-11-16-7-8(17-11)6-9(14)13(20)21/h7,9-10H,4-6,14H2,1-3H3,(H3-,15,16,17,19,20,21)/p+1/t9-,10+/m0/s1
InChIKeyFOOBQHKMWYGHCE-VHSXEESVSA-O

Chemical Details

Formal Charge1
Atom Count45
Chiral Atom Count2
Bond Count45
Aromatic Bond Count5

Drug Info: DrugBank

DrugBank IDDB03223 
NameDiphthamide
Groups experimental
Synonyms
  • Diphthamide
  • 2-(3-Carboxyamido-3-(Trimethylammonio)Propyl)Histidine
Categories
  • Amino Acids
  • Amino Acids, Cyclic
  • Amino Acids, Peptides, and Proteins
CAS number75645-22-6

Drug Targets

NameTarget SequencePharmacological ActionActions
Elongation factor 2MVNFTVDQIRAIMDKKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASAR...unknown
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 5460185, 46878402