D27

2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid

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Chemical Component Summary
Name	2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid
Identifiers	2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid
Formula	C₁₈ H₁₇ N O₅
Molecular Weight	327.331
Type	NON-POLYMER
Isomeric SMILES	COc1ccc(cc1OC)\C=C\C(=O)Nc2ccccc2C(=O)O
InChI	InChI=1S/C18H17NO5/c1-23-15-9-7-12(11-16(15)24-2)8-10-17(20)19-14-6-4-3-5-13(14)18(21)22/h3-11H,1-2H3,(H,19,20)(H,21,22)/b10-8+
InChIKey	NZHGWWWHIYHZNX-CSKARUKUSA-N

Chemical Details
Formal Charge	0
Atom Count	41
Chiral Atom Count	0
Bond Count	42
Aromatic Bond Count	12

Drug Info: DrugBank

DrugBank ID	DB07615
Name	Tranilast
Groups	investigational
Description	Tranilast is an antiallergic drug developed by Kissei Pharmaceuticals. In 1982, it was approved in Japan and South Korea for the management of bronchial asthma. Indications for keloid and hypertrophic scar were added in 1993. It has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
Synonyms	Tranilast N-(3,4-Dimethoxycinnamoyl)anthranilic acid Tranilastum
Indication	For the treatment of bronchial asthma, keloid and hypertrophic scar, and allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
Categories	Acids, Carbocyclic Agents causing hyperkalemia Aminobenzoates Analgesics Analgesics, Non-Narcotic Anti-Allergic Agents Anti-Inflammatory Agents Antiarrhythmic agents Antiplatelet agents Antirheumatic Agents Benzene Derivatives Benzoates Bradycardia-Causing Agents Calcium Channel Blockers Calcium-Regulating Hormones and Agents Cardiovascular Agents Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Hematologic Agents Histamine Agents Membrane Transport Modulators Neurotransmitter Agents Peripheral Nervous System Agents Sensory System Agents
CAS number	53902-12-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Hematopoietic prostaglandin D synthase	MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGK...	unknown	inhibitor
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate
Cytochrome P450 2C9	MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDI...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682