CBO

CARBENOXOLONE

Find entries where: CBO

is present as a standalone ligand in 5 entries

Find related ligands:

Chemical Component Summary
Name	CARBENOXOLONE
Identifiers	(2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-10-(4-hydroxy-4-oxo-butanoyl)oxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylic acid
Formula	C₃₄ H₅₀ O₇
Molecular Weight	570.757
Type	NON-POLYMER
Isomeric SMILES	CC1([C@@H]2CC[C@@]3([C@@H]([C@]2(CC[C@@H]1OC(=O)CCC(=O)O)C)C(=O)C=C4[C@]3(CC[C@@]5([C@H]4C[C@@](CC5)(C)C(=O)O)C)C)C)C
InChI	InChI=1S/C34H50O7/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40)/t21-,23-,24-,27+,30+,31-,32-,33+,34+/m0/s1
InChIKey	OBZHEBDUNPOCJG-WBXJDKIVSA-N

Chemical Details
Formal Charge	0
Atom Count	91
Chiral Atom Count	9
Bond Count	95
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB02329
Name	Carbenoxolone
Groups	experimental
Description	An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity. [PubChem]
Synonyms	Carbenoxolone Carbenoxolone disodium Carbenoxolona
Categories	Alimentary Tract and Metabolism Anti-Ulcer Agents Drugs for Acid Related Disorders Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) Gastrointestinal Agents Pentacyclic Triterpenes Terpenes Triterpenes
ATC-Code	A02BX01 A02BX71 A02BX51
CAS number	5697-56-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	MNDLSGKTVIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATAREL...	unknown
Corticosteroid 11-beta-dehydrogenase isozyme 1	MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREM...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682