Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.[L36773] In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA due to an unresolved confirmatory study required to fulfill the accelerated approval requirements.[L44251]
Synonyms
4-(aminomethyl)benzenesulfonamide
Maphenidum
Mafenide
Mafenide Acetate
4-Homosufanilamide
Bensulfamide
Brand Names
Mafenide Acetate
Sulfamylon Cream - 8.5%
Sulfamylon
Mafenide acetate
Indication
Indicated for use as an adjunctive topical antimicrobial agent to control bacterial infection when used under moist dressings over meshed autografts on excised burn wounds.[label]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
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