3QB

LINCOMYCIN

Find entries where: 3QB

is present as a standalone ligand in 4 entries

Find related ligands:

Chemical Component Summary
Name	LINCOMYCIN
Synonyms	methyl (5R)-5-[(1R,2R)-2-hydroxy-1-{[(4R)-1-methyl-4-propyl-L-prolyl]amino}propyl]-1-thio-beta-L-arabinopyranoside
Identifiers	(2S,4R)-1-methyl-N-[(1R,2R)-1-[(2R,3R,4S,5R,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]-2-oxidanyl-propyl]-4-propyl-pyrrolidine-2-carboxamide
Formula	C₁₈ H₃₄ N₂ O₆ S
Molecular Weight	406.537
Type	NON-POLYMER
Isomeric SMILES	CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O
InChI	InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)/t9-,10-,11+,12-,13+,14-,15-,16-,18-/m1/s1
InChIKey	OJMMVQQUTAEWLP-KIDUDLJLSA-N

Chemical Details
Formal Charge	0
Atom Count	61
Chiral Atom Count	9
Bond Count	62
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB01627
Name	Lincomycin
Groups	vet_approved approved
Description	Lincomycin is a lincosamide antibiotic first isolated from the soil bacterium _Streptomyces lincolnensis_ in Lincoln, Nebraska.[A190621] Clinical use of lincomycin has largely been superseded by its semisynthetic derivative [clindamycin] due to its higher efficacy and a wider range of susceptible organisms, though lincomycin remains in use.[A190657, A190621] Lincomycin was approved by the FDA on December 29, 1964.[L33214]
Synonyms	Lincomicina LCM Lincomycinum Lincomycin hydrochloride monohydrate Cillimycin Lincomycine Lincomycin Lincomycin hydrochloride
Brand Names	Lincomycin Hydrochloride Lincomycin Lincocin Lincomycin hydrochloride
Indication	Lincomycin is indicated for the treatment of serious bacterial infections by susceptible strains of streptococci, pneumococci, and staphylococci in patients who are allergic to penicillins or for situations in which a penicillin is deemed inappropriate. As with all antibacterial agents, lincomycin should only be used to treat infections proven or strongly suspected to be caused by susceptible bacteria.[L33214]
Categories	Agents that produce neuromuscular block (indirect) Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use Carbohydrates Enzyme Inhibitors Glycosides Lincosamide Antibacterial Lincosamides Macrolides, Lincosamides and Streptogramins Neurotoxic agents Protein Synthesis Inhibitors Pyrrolidines
ATC-Code	J01FF02
CAS number	154-21-2

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
23S ribosomal RNA	-	unknown	binder
Alpha-1-acid glycoprotein 1	MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDQITGKWFYIASAF...	unknown	binder

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682