212

ALENDRONATE

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is present as a standalone ligand in 2 entries

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Chemical Component Summary
Name	ALENDRONATE
Synonyms	(4-AMINO-1-HYDROXY-1-PHOSPHONO-BUTYL)PHOSPHONIC ACID
Identifiers	(4-amino-1-hydroxy-1-phosphono-butyl)phosphonic acid
Formula	C₄ H₁₃ N O₇ P₂
Molecular Weight	249.096
Type	NON-POLYMER
Isomeric SMILES	C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
InChI	InChI=1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12)
InChIKey	OGSPWJRAVKPPFI-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	27
Chiral Atom Count	0
Bond Count	26
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00630
Name	Alendronic acid
Groups	approved
Description	Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label][A959].
Synonyms	Alendronate disodium Alendronate Alendronate sodium Acide Alendronique 4-amino-1-hydroxybutane-1,1-diphosphonic acid ABDP (4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid) Acido Alendronico Alendronate sodium anhydrous Alendronic acid Alendronate calcium (4-amino-1-hydroxybutylidene)bisphosphonic acid Acidum Alendronicum
Brand Names	Apo-alendronate PMS-alendronate Jamp-alendronate Apo-alendronate/vitamin D3 Accel-alendronate Mylan-alendronate Q-alendronate Act Alendronate Teva-alendronate/cholecalciferol Gen-alendronate Jamp Alendronate / Vitamin D3 Alendronate Binosto Dom-alendronate-FC PHL-alendronate Teva-alendronate Ratio Alendronate Fosavance Alendronate-70 Ag-alendronate Mint-alendronate Ach-alendronate Vantavo Ran-alendronate Adrovance Dom-alendronate Riva-alendronate Jamp Alendronate Sodium PMS-alendronate-FC Fosamax Plus D Fosamax Sandoz Alendronate Alendronate-cholecalciferol Alendronate Sodium Van-alendronate Riva Alendronate M-alendronate Ava-alendronate Sandoz Alendronate/cholecalciferol Nra-alendronate Ag-alendronate Sodium Auro-alendronate
Indication	Alendronic acid is indicated for the treatment and prevention of osteoporosis in men and postmenopausal women, treatment of glucocorticoid-induced osteoporosis, and Paget's disease of bone[FDA Label][A959,A176750]. However, alendronic acid is not indicated for use in pediatric populations or patients with a creatinine clearance <35mL/min[FDA Label].
Categories	Agents Causing Muscle Toxicity Bisphosphonates Bone Density Conservation Agents Drugs Affecting Bone Structure and Mineralization Drugs for Treatment of Bone Diseases Musculo-Skeletal System Organophosphonates Organophosphorus Compounds
ATC-Code	M05BB03 M05BA04 M05BB06 M05BB05
CAS number	66376-36-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Farnesyl pyrophosphate synthase	MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCW...	unknown	inhibitor
Hydroxylapatite	-	unknown	antagonist
Tyrosine-protein phosphatase non-receptor type 4	MTSRFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQ...	unknown	inhibitor
Receptor-type tyrosine-protein phosphatase S	MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVA...	unknown	inhibitor
Receptor-type tyrosine-protein phosphatase epsilon	MEPLCPLLLVGFSLPLARALRGNETTADSNETTTTSGPPDPGASQPLLAW...	unknown	inhibitor
V-type proton ATPase catalytic subunit A	MDFSKLPKILDEDKESTFGYVHGVSGPVVTACDMAGAAMYELVRVGHSEL...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682