9AYK

Cryo-EM structure of human Cav3.2 with ML218

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Voltage-dependent T-type calcium channel subunit alpha-1H	calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity low voltage-gated calcium channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity low voltage-gated calcium channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity high voltage-gated calcium channel activity scaffold protein binding protein binding binding voltage-gated sodium channel activity sodium channel activity sodium ion transmembrane transporter activity cation binding ion binding metal ion binding small molecule binding	heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process heart contraction blood circulation cellular biosynthetic process steroid metabolic process heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process heart contraction blood circulation cellular biosynthetic process steroid metabolic process organic hydroxy compound metabolic process lipid biosynthetic process alcohol metabolic process cortisol metabolic process organic substance metabolic process cellular ketone metabolic process organic substance biosynthetic process small molecule metabolic process primary alcohol biosynthetic process steroid biosynthetic process steroid hormone biosynthetic process tertiary alcohol metabolic process olefinic compound biosynthetic process small molecule biosynthetic process cellular metabolic process primary metabolic process cortisol biosynthetic process glucocorticoid metabolic process glucocorticoid biosynthetic process organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process organic hydroxy compound biosynthetic process alcohol biosynthetic process tertiary alcohol biosynthetic process olefinic compound metabolic process metabolic process cellular process ketone biosynthetic process lipid metabolic process primary alcohol metabolic process cellular response to stimulus cellular response to inorganic substance cellular response to metal ion response to stimulus response to potassium ion response to inorganic substance cellular response to chemical stimulus response to metal ion response to chemical cellular response to potassium ion developmental process muscle structure development animal organ development anatomical structure development muscle organ development response to organic substance response to endogenous stimulus cellular response to endogenous stimulus response to hormone cellular response to organic substance cellular response to hormone stimulus membrane depolarization during action potential membrane depolarization action potential regulation of biological quality regulation of membrane potential transmembrane transport localization transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport import into cell calcium ion transmembrane import into cytosol monoatomic ion transmembrane transport import across plasma membrane inorganic cation import across plasma membrane calcium ion transport metal ion transport monoatomic cation transmembrane transport calcium ion import across plasma membrane inorganic ion import across plasma membrane monoatomic ion transport calcium ion import calcium ion import into cytosol monoatomic cation transport calcium ion transmembrane transport sexual reproduction regulation of reproductive process reproductive process fertilization positive regulation of biological process positive regulation of acrosome reaction acrosome reaction regulation of acrosome reaction single fertilization positive regulation of reproductive process regulation of localization regulated exocytosis regulation of cellular process regulation of calcium ion-dependent exocytosis positive regulation of secretion by cell vesicle-mediated transport positive regulation of exocytosis regulation of regulated secretory pathway secretion by cell regulation of secretion by cell positive regulation of secretion positive regulation of regulated secretory pathway positive regulation of cellular process calcium-ion regulated exocytosis positive regulation of calcium ion-dependent exocytosis secretion regulation of transport export from cell regulation of vesicle-mediated transport regulation of secretion exocytosis positive regulation of transport regulation of exocytosis mineralocorticoid biosynthetic process aldehyde biosynthetic process C21-steroid hormone metabolic process mineralocorticoid metabolic process aldosterone metabolic process cellular aldehyde metabolic process hormone biosynthetic process aldosterone biosynthetic process regulation of hormone levels C21-steroid hormone biosynthetic process hormone metabolic process cellular developmental process myoblast fusion cell-cell fusion muscle cell differentiation myotube differentiation syncytium formation by plasma membrane fusion anatomical structure morphogenesis cell differentiation anatomical structure formation involved in morphogenesis syncytium formation striated muscle cell differentiation muscle contraction muscle system process	membrane cellular anatomical entity cell periphery plasma membrane cell projection neuron projection plasma membrane bounded cell projection protein-containing complex sodium channel complex voltage-gated sodium channel complex plasma membrane protein complex membrane protein complex cation channel complex transporter complex membrane cellular anatomical entity cell periphery plasma membrane cell projection neuron projection plasma membrane bounded cell projection protein-containing complex sodium channel complex voltage-gated sodium channel complex plasma membrane protein complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex voltage-gated calcium channel complex calcium channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005821	Ion transport domain	Domain
A	IPR005445	Voltage-dependent calcium channel, T-type, alpha-1 subunit	Family
A	IPR043203	Voltage-gated cation channel calcium and sodium	Family
A	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O95180	childhood absence epilepsy hyperaldosteronism, familial, type IV absence epilepsy epilepsy epilepsy, childhood absence, susceptibility to, 6 juvenile absence epilepsy primary aldosteronism epilepsy, childhood absence, susceptibility to, 1 hypertensive disorder lung carcinoma osteosarcoma psoriasis autism intellectual disability malignant mesothelioma childhood absence epilepsy hyperaldosteronism, familial, type IV absence epilepsy epilepsy epilepsy, childhood absence, susceptibility to, 6 juvenile absence epilepsy primary aldosteronism epilepsy, childhood absence, susceptibility to, 1 hypertensive disorder lung carcinoma osteosarcoma psoriasis autism intellectual disability malignant mesothelioma peripheral nervous system disease autism spectrum disorder

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.