Annotations: 8W42

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Transthyretin (synonym: prealbumin)	8040289	3000848	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Transthyretin (synonym: prealbumin)	8040289	3000848	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00576	e8w42A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF00576	ECOD (1.6)
B	PF00576	e8w42B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Prealbumin-like	F: PF00576	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Transthyretin	hormone activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity thyroid hormone binding hormone binding identical protein binding	organonitrogen compound metabolic process purine nucleobase metabolic process primary metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process nucleobase-containing small molecule metabolic process nucleobase metabolic process small molecule metabolic process metabolic process	extracellular region cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure lytic vacuole intracellular vesicle membrane-enclosed lumen extracellular region cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle lysosome vesicle lumen azurophil granule vacuole intracellular membrane-bounded organelle secretory granule lumen azurophil granule lumen organelle lumen secretory granule primary lysosome secretory vesicle cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036817	Transthyretin/hydroxyisourate hydrolase domain superfamily	Homologous Superfamily
A, B	IPR023418	Transthyretin, thyroxine binding site	Binding Site
A, B	IPR023419	Transthyretin, conserved site	Conserved Site
A, B	IPR023416	Transthyretin/hydroxyisourate hydrolase domain	Domain
A, B	IPR000895	Transthyretin/hydroxyisourate hydrolase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P02766	amyloidosis familial amyloid neuropathy carpal tunnel syndrome hyperthyroxinemia, dystransthyretinemic lattice corneal dystrophy peripheral neuropathy Transthyretin related familial amyloid cardiomyopathy carpal tunnel syndrome 1 diabetes mellitus pancreatic intraductal papillary-mucinous carcinoma drug-induced liver injury peripheral nervous system disease acquired metabolic disease Riley-Day syndrome hydrocephalus amyloidosis familial amyloid neuropathy carpal tunnel syndrome hyperthyroxinemia, dystransthyretinemic lattice corneal dystrophy peripheral neuropathy Transthyretin related familial amyloid cardiomyopathy carpal tunnel syndrome 1 diabetes mellitus pancreatic intraductal papillary-mucinous carcinoma drug-induced liver injury peripheral nervous system disease acquired metabolic disease Riley-Day syndrome hydrocephalus intellectual disability Charcot-Marie-Tooth disease medulloblastoma dilated cardiomyopathy osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis acute kidney failure schizophrenia kidney disease lung benign neoplasm lymphatic system disease depressive disorder periodic fever syndrome polyneuropathy rheumatoid arthritis heart disease Sjogren syndrome hereditary amyloidosis hypertrophic cardiomyopathy lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.