8T70

Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM peptide

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01239	e8t70A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF01239	ECOD (1.6)
B	PF00432	e8t70B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: alpha/alpha toroid (From Topology)	T: alpha/alpha toroid	F: PF00432	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01239	Protein prenyltransferase alpha subunit repeat (PPTA)	Protein prenyltransferase alpha subunit repeat	-	Repeat
B	PF00432	Prenyltransferase and squalene oxidase repeat (Prenyltrans)	Prenyltransferase and squalene oxidase repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	protein farnesyltransferase activity catalytic activity, acting on a protein protein prenyltransferase activity prenyltransferase activity transferase activity catalytic activity transferase activity, transferring alkyl or aryl (other than methyl) groups CAAX-protein geranylgeranyltransferase activity protein geranylgeranyltransferase activity	-	protein-containing complex protein farnesyltransferase complex intracellular anatomical structure catalytic complex polyprenyl diphosphate synthase complex cytoplasm cellular anatomical entity transferase complex CAAX-protein geranylgeranyltransferase complex intracellular protein-containing complex
B	Protein farnesyltransferase subunit beta	protein farnesyltransferase activity catalytic activity, acting on a protein protein prenyltransferase activity prenyltransferase activity transferase activity catalytic activity transferase activity, transferring alkyl or aryl (other than methyl) groups cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	cellular metabolic process metabolic process cellular process prenylation	protein-containing complex protein farnesyltransferase complex intracellular anatomical structure catalytic complex polyprenyl diphosphate synthase complex cytoplasm cellular anatomical entity transferase complex
C [auth P]	MET-ILE-ILE-MET	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002088	Protein prenyltransferase, alpha subunit	Repeat
B	IPR045089	Prenyltransferase subunit beta	Family
B	IPR001330	PFTB repeat	Repeat
B	IPR026872	Protein farnesyltransferase subunit beta	Family
B	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.