8QN5

M. tuberculosis salicylate synthase MbtI in complex with methyl-AMT (new crystal form)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ADC synthase	8041692	3001093	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	ADC synthase	8041692	3001093	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	ADC synthase	8041692	3001093	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ADC synthase	8041692	3001093	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00425	e8qn5A1	A: a+b duplicates or obligate multimers	X: ADC synthase (From Topology)	H: ADC synthase (From Topology)	T: ADC synthase	F: PF00425	ECOD (1.6)
C	PF00425	e8qn5C1	A: a+b duplicates or obligate multimers	X: ADC synthase (From Topology)	H: ADC synthase (From Topology)	T: ADC synthase	F: PF00425	ECOD (1.6)
D	PF00425	e8qn5D1	A: a+b duplicates or obligate multimers	X: ADC synthase (From Topology)	H: ADC synthase (From Topology)	T: ADC synthase	F: PF00425	ECOD (1.6)
B	PF00425	e8qn5B1	A: a+b duplicates or obligate multimers	X: ADC synthase (From Topology)	H: ADC synthase (From Topology)	T: ADC synthase	F: PF00425	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Salicylate synthase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding isomerase activity chorismate mutase activity catalytic activity intramolecular transferase activity isochorismate pyruvate lyase activity lyase activity carbon-oxygen lyase activity isochorismate synthase activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding isomerase activity chorismate mutase activity catalytic activity intramolecular transferase activity isochorismate pyruvate lyase activity lyase activity carbon-oxygen lyase activity isochorismate synthase activity intramolecular hydroxytransferase activity oxo-acid-lyase activity carbon-carbon lyase activity	catechol-containing siderophore biosynthetic process organic hydroxy compound metabolic process catechol-containing compound metabolic process secondary metabolic process organic cyclic compound metabolic process siderophore biosynthetic process organic substance metabolic process biosynthetic process peptide biosynthetic process secondary metabolite biosynthetic process siderophore metabolic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process catechol-containing siderophore biosynthetic process organic hydroxy compound metabolic process catechol-containing compound metabolic process secondary metabolic process organic cyclic compound metabolic process siderophore biosynthetic process organic substance metabolic process biosynthetic process peptide biosynthetic process secondary metabolite biosynthetic process siderophore metabolic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process organic cyclic compound biosynthetic process organic substance biosynthetic process phenol-containing compound biosynthetic process catechol-containing compound biosynthetic process metabolic process nonribosomal peptide biosynthetic process peptide metabolic process response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism response to external stimulus response to biotic stimulus biological process involved in interaction with host biological process involved in symbiotic interaction response to host immune response response to host response to external biotic stimulus oxoacid metabolic process cellular biosynthetic process organonitrogen compound biosynthetic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process tryptophan biosynthetic process indole-containing compound biosynthetic process indolalkylamine metabolic process small molecule metabolic process indolalkylamine biosynthetic process organonitrogen compound metabolic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process tryptophan metabolic process amine metabolic process amino acid biosynthetic process amine biosynthetic process cellular process biogenic amine metabolic process alpha-amino acid biosynthetic process monocarboxylic acid biosynthetic process benzene-containing compound metabolic process salicylic acid biosynthetic process salicylic acid metabolic process monocarboxylic acid metabolic process cellular response to stimulus response to nutrient levels inorganic ion homeostasis homeostatic process cellular response to starvation cellular response to iron ion starvation cellular response to nutrient levels intracellular iron ion homeostasis cellular homeostasis chemical homeostasis cellular response to stress intracellular monoatomic cation homeostasis response to stress monoatomic ion homeostasis intracellular chemical homeostasis response to starvation monoatomic cation homeostasis intracellular monoatomic ion homeostasis	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR019999	Anthranilate synthase component I-like	Family
A, B, C, D	IPR019996	Salicylate synthase	Family
A, B, C, D	IPR005801	ADC synthase	Homologous Superfamily
A, B, C, D	IPR015890	Chorismate-utilising enzyme, C-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.