8K1Z

Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 200 mM KCl

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: PDBTM

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07885	Ion channel (Ion_trans_2)	Ion channel	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Potassium channel subfamily K member 9	monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity monoatomic ion channel activity potassium ion leak channel activity potassium channel activity monoatomic cation channel activity passive transmembrane transporter activity narrow pore channel activity leak channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity monoatomic ion channel activity potassium ion leak channel activity potassium channel activity monoatomic cation channel activity passive transmembrane transporter activity narrow pore channel activity leak channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity gated channel activity outward rectifier potassium channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity voltage-gated potassium channel activity	localization transport monoatomic ion transport potassium ion transport monoatomic cation transport establishment of localization metal ion transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport cellular process localization transport monoatomic ion transport potassium ion transport monoatomic cation transport establishment of localization metal ion transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport cellular process stabilization of membrane potential biological regulation regulation of biological quality regulation of membrane potential import into cell import across plasma membrane inorganic cation import across plasma membrane inorganic ion import across plasma membrane potassium ion import across plasma membrane	cell periphery plasma membrane membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure transport vesicle synapse intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle presynapse cytoplasmic vesicle cell periphery plasma membrane membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure transport vesicle synapse intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle presynapse cytoplasmic vesicle synaptic vesicle organelle cell junction secretory vesicle cytoplasm vesicle exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR003280	Two pore domain potassium channel	Family
A, B	IPR003092	Two pore domain potassium channel, TASK family	Family
A, B	IPR013099	Potassium channel domain	Domain
A, B	IPR005407	Potassium channel subfamily K member 9	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9NPC2	Birk-Barel syndrome childhood absence epilepsy absence epilepsy intellectual disability juvenile absence epilepsy pilocytic astrocytoma glioblastoma malignant ependymoma osteosarcoma medulloblastoma ovarian cancer subependymal giant cell astrocytoma

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.