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Crystal structure of diphtheria toxin H223Q/H257Q double mutant (pH 4.5) External Resource: Annotation Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A PF01324 e8g0gA3 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Common fold of diphtheria toxin/transcription factors/cytochrome f F: PF01324 ECOD (1.6) A PF02764 e8g0gA1 A: alpha arrays X: Toxins' membrane translocation domains H: Diphtheria toxin, middle domain (From Topology) T: Diphtheria toxin, middle domain F: PF02764 ECOD (1.6) A PF02763 e8g0gA2 A: a+b complex topology X: ADP-ribosylation (From Topology) H: ADP-ribosylation (From Topology) T: ADP-ribosylation F: PF02763 ECOD (1.6) B PF01324 e8g0gB3 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Common fold of diphtheria toxin/transcription factors/cytochrome f F: PF01324 ECOD (1.6) B PF02764 e8g0gB2 A: alpha arrays X: Toxins' membrane translocation domains H: Diphtheria toxin, middle domain (From Topology) T: Diphtheria toxin, middle domain F: PF02764 ECOD (1.6) B PF02763 e8g0gB1 A: a+b complex topology X: ADP-ribosylation (From Topology) H: ADP-ribosylation (From Topology) T: ADP-ribosylation F: PF02763 ECOD (1.6)
Chains Accession Name Description Comments Source PF02764 Diphtheria toxin, T domain (Diphtheria_T) Diphtheria toxin, T domain Central domain of diphtheria toxin is the translocation (T) domain. pH induced conformational change in this domain triggers insertion into the endosomal membrane and facilitates the transfer of the catalytic domain into the cytoplasm. Domain PF02763 Diphtheria toxin, C domain (Diphtheria_C) Diphtheria toxin, C domain N-terminal catalytic (C) domain - blocks protein synthesis by transfer of ADP-ribose from NAD to a diphthamide residue of EF-2. Domain PF01324 Diphtheria toxin, R domain (Diphtheria_R) Diphtheria toxin, R domain C-terminal receptor binding (R) domain - binds to cell surface receptor, permitting the toxin to enter the cell by receptor mediated endocytosis. Domain
Chains Polymer Molecular Function Biological Process Cellular Component Diphtheria toxin -