Annotations: 8CGW

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8054097	3000116	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Metalloproteases (zincins) catalytic domain	8054095	3001975	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Leukotriene A4 hydrolase N-terminal domain	8054094	3000390	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ERAP1 insert domain	8054096	3002272	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Leukotriene A4 hydrolase N-terminal domain	8054094	3000390	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8054097	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Metalloproteases (zincins) catalytic domain	8054095	3001975	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ERAP1 insert domain	8054096	3002272	SCOP2B (2022-06-29)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Leucyl-cystinyl aminopeptidase, pregnancy serum form	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity aminopeptidase activity metalloaminopeptidase activity exopeptidase activity metalloexopeptidase activity binding peptide binding cation binding transition metal ion binding zinc ion binding peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity aminopeptidase activity metalloaminopeptidase activity exopeptidase activity metalloexopeptidase activity binding peptide binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular catabolic process organic substance metabolic process catabolic process cellular metabolic process metabolic process cellular process organic substance catabolic process peptide metabolic process peptide catabolic process multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation cellular catabolic process organic substance metabolic process catabolic process cellular metabolic process metabolic process cellular process organic substance catabolic process peptide metabolic process peptide catabolic process multicellular organismal process system process circulatory system process regulation of blood pressure biological regulation regulation of biological quality blood circulation multi-multicellular organism process reproductive process female pregnancy multi-organism reproductive process organonitrogen compound catabolic process organonitrogen compound metabolic process primary metabolic process protein catabolic process macromolecule catabolic process protein metabolic process macromolecule metabolic process regulation of biological process signaling cell-cell signaling cell communication cellular response to stimulus regulation of cellular process response to stimulus signal transduction protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent antigen processing and presentation immune system process antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen via MHC class I antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen negative regulation of cold-induced thermogenesis homeostatic process negative regulation of metabolic process negative regulation of biological process adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis regulation of multicellular organismal process negative regulation of multicellular organismal process regulation of metabolic process proteolysis	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle early endosome endosome intracellular vesicle membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle early endosome endosome intracellular vesicle membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle vesicle endosome lumen early endosome lumen cell periphery plasma membrane cytoplasmic vesicle membrane vesicle membrane organelle membrane vacuolar membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane lysosome extracellular region perinuclear region of cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001930	Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase	Family
A, B	IPR042097	Aminopeptidase N-like , N-terminal domain superfamliy	Homologous Superfamily
A, B	IPR024571	ERAP1-like C-terminal domain	Domain
A, B	IPR027268	Peptidase M4/M1, CTD superfamily	Homologous Superfamily
A, B	IPR034016	Aminopeptidase N-type	Family
A, B	IPR014782	Peptidase M1, membrane alanine aminopeptidase	Domain
A, B	IPR045357	Aminopeptidase N-like , N-terminal domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9UIQ6	Memory Disorders ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor atrial fibrillation birdshot chorioretinopathy glioblastoma juvenile dermatomyositis malignant glioma medulloblastoma myopathy pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia amyotrophic lateral sclerosis psoriasis Memory Disorders ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor atrial fibrillation birdshot chorioretinopathy glioblastoma juvenile dermatomyositis malignant glioma medulloblastoma myopathy pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia amyotrophic lateral sclerosis psoriasis attention deficit hyperactivity disorder, inattentive type Crohn disease inflammatory bowel disease juvenile idiopathic arthritis malignant pancreatic neoplasm osteosarcoma pancreatic intraductal papillary-mucinous carcinoma Pick disease ankylosing spondylitis spina bifida atypical teratoid rhabdoid tumor ductal breast carcinoma in situ invasive ductal breast carcinoma large cell medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.