Annotations: 7Y7S

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Two-barrel nucleic acid polymerases	8055682	3001330	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Two-barrel nucleic acid polymerases	8055683	3001330	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Two-barrel nucleic acid polymerases	8055682	3001330	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Two-barrel nucleic acid polymerases	8055683	3001330	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05183	e7y7sA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: PF05183	ECOD (1.6)
A	PF05183	e7y7sA2	A: alpha complex topology	X: RNAi polymerase helical domain (From Topology)	H: RNAi polymerase helical domain (From Topology)	T: RNAi polymerase helical domain	F: PF05183	ECOD (1.6)
A	PF05183	e7y7sA4	A: a+b complex topology	X: RNAi polymerase N-terminal domain (From Topology)	H: RNAi polymerase N-terminal domain (From Topology)	T: RNAi polymerase N-terminal domain	F: PF05183	ECOD (1.6)
B	PF05183	e7y7sB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: PF05183	ECOD (1.6)
B	PF05183	e7y7sB3	A: alpha complex topology	X: RNAi polymerase helical domain (From Topology)	H: RNAi polymerase helical domain (From Topology)	T: RNAi polymerase helical domain	F: PF05183	ECOD (1.6)
B	PF05183	e7y7sB4	A: a+b complex topology	X: RNAi polymerase N-terminal domain (From Topology)	H: RNAi polymerase N-terminal domain (From Topology)	T: RNAi polymerase N-terminal domain	F: PF05183	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05183	RNA dependent RNA polymerase (RdRP)	RNA dependent RNA polymerase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, D [auth I]	DNA (5'-D(GPAPAPCPTPAPTPGPGPTPCPGPGPA)-3')	-	-	-
A, B	RNA-dependent RNA polymerase	5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups RNA binding binding organic cyclic compound binding nucleic acid binding cation binding 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups RNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding	regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	-
E [auth D], F [auth J]	RNA (5'-R(UPCPCPGPAPCP*C)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR007855	RNA-dependent RNA polymerase, eukaryotic-type	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.