7U5V

Crystal structure of the Mixed Lineage Leukaemia (MLL1) SET Domain with the cofactor product S-Adenosylhomocysteine and Borealin peptide

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00856	e7u5vA1	A: beta barrels	X: beta-clip	H: SET domain-like (From Topology)	T: SET domain-like	F: PF00856	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Histone-lysine N-methyltransferase 2A	sequence-specific DNA binding DNA binding binding organic cyclic compound binding unmethylated CpG binding nucleic acid binding protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity histone H3K4 methyltransferase activity sequence-specific DNA binding DNA binding binding organic cyclic compound binding unmethylated CpG binding nucleic acid binding protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups transferase activity S-adenosylmethionine-dependent methyltransferase activity histone methyltransferase activity histone H3K4 methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity histone H3K4 trimethyltransferase activity S-methyltransferase activity protein-cysteine methyltransferase activity histone H3K4 monomethyltransferase activity DNA secondary structure binding minor groove of adenine-thymine-rich DNA binding identical protein binding protein binding modification-dependent protein binding lysine-acetylated histone binding histone binding acetylation-dependent protein binding protein-containing complex binding chromatin binding protein homodimerization activity protein dimerization activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription transcription by RNA polymerase II chromatin organization organic substance biosynthetic process positive regulation of macromolecule metabolic process transcription initiation at RNA polymerase II promoter regulation of biological process cellular metabolic process regulation of cellular metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription transcription by RNA polymerase II chromatin organization organic substance biosynthetic process positive regulation of macromolecule metabolic process transcription initiation at RNA polymerase II promoter regulation of biological process cellular metabolic process regulation of cellular metabolic process primary metabolic process regulation of gene expression organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process protein-DNA complex organization cellular component organization RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process chromatin remodeling cellular component organization or biogenesis positive regulation of cellular process regulation of biosynthetic process protein-containing complex organization epigenetic regulation of gene expression biological regulation regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of cellular biosynthetic process positive regulation of gene expression cellular process positive regulation of cellular biosynthetic process behavior multicellular organismal process exploration behavior organonitrogen compound metabolic process macromolecule modification protein metabolic process protein modification process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis homeostasis of number of cells apoptotic process cell death programmed cell death response to stimulus response to potassium ion response to metal ion response to chemical response to inorganic substance rhythmic process circadian regulation of gene expression circadian rhythm developmental process cellular developmental process hemopoiesis animal organ development cell development embryo development multicellular organism development embryonic hemopoiesis cell differentiation anatomical structure development embryonic organ development immune system development spleen development immune system process hematopoietic or lymphoid organ development system development fibroblast proliferation cell population proliferation negative regulation of cell population proliferation negative regulation of biological process regulation of fibroblast proliferation regulation of cell population proliferation negative regulation of cellular process negative regulation of fibroblast proliferation definitive hemopoiesis regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription regulation of RNA biosynthetic process positive regulation of RNA biosynthetic process cellular component biogenesis cellular component assembly protein-containing complex assembly cellular response to endogenous stimulus cellular response to growth factor stimulus response to transforming growth factor beta cellular response to transforming growth factor beta stimulus response to endogenous stimulus response to growth factor response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning response to radiation response to abiotic stimulus regulation of neuronal synaptic plasticity regulation of synaptic plasticity trans-synaptic signaling regulation of short-term neuronal synaptic plasticity regulation of signaling modulation of chemical synaptic transmission signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of biological quality mononuclear cell differentiation lymphocyte activation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response leukocyte activation alpha-beta T cell differentiation type 2 immune response T cell activation involved in immune response alpha-beta T cell activation involved in immune response T cell activation CD4-positive, alpha-beta T cell activation leukocyte activation involved in immune response alpha-beta T cell activation T-helper 2 cell differentiation T cell differentiation lymphocyte activation involved in immune response immune response T-helper cell differentiation cell activation T cell differentiation involved in immune response immune effector process leukocyte differentiation membrane depolarization regulation of membrane potential post-embryonic development anterior/posterior pattern specification pattern specification process regionalization negative regulation of DNA methylation-dependent heterochromatin formation negative regulation of heterochromatin formation negative regulation of cellular metabolic process regulation of heterochromatin formation regulation of chromatin organization negative regulation of cellular component organization regulation of DNA methylation-dependent heterochromatin formation negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of cellular component organization negative regulation of chromatin organization DNA methylation-dependent heterochromatin formation negative regulation of macromolecule metabolic process heterochromatin formation negative regulation of biosynthetic process facultative heterochromatin formation	membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen intracellular organelle nucleoplasm membrane-bounded organelle protein-containing complex histone methyltransferase complex intracellular anatomical structure catalytic complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity transferase complex intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle methyltransferase complex nuclear lumen cytoplasm cytosol MLL1/2 complex MLL1 complex
B [auth C]	Borealin	-	cellular process cell cycle mitotic cell cycle mitotic spindle elongation spindle midzone assembly spindle elongation non-membrane-bounded organelle assembly microtubule cytoskeleton organization cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cellular component organization or biogenesis chromosome segregation cellular process cell cycle mitotic cell cycle mitotic spindle elongation spindle midzone assembly spindle elongation non-membrane-bounded organelle assembly microtubule cytoskeleton organization cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly organelle organization nuclear division mitotic cell cycle process nuclear chromosome segregation microtubule-based process mitotic spindle midzone assembly cytoskeleton organization cytoskeleton-dependent cytokinesis mitotic cytokinesis cytokinesis cell division cellular response to stimulus positive regulation of cell communication regulation of cellular process regulation of cell cycle phase transition positive regulation of signal transduction response to stimulus positive regulation of cell cycle checkpoint negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of signal transduction regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication regulation of cell cycle checkpoint negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction mitotic sister chromatid separation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling regulation of biological process negative regulation of cellular component organization regulation of cell cycle process regulation of spindle checkpoint positive regulation of intracellular signal transduction regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation regulation of response to stimulus positive regulation of mitotic cell cycle spindle assembly checkpoint regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic spindle checkpoint signaling regulation of mitotic cell cycle spindle assembly checkpoint spindle assembly checkpoint signaling positive regulation of biological process cell cycle phase transition regulation of mitotic metaphase/anaphase transition positive regulation of response to stimulus regulation of mitotic cell cycle regulation of intracellular signal transduction negative regulation of cellular process positive regulation of cell cycle process negative regulation of mitotic metaphase/anaphase transition regulation of cell cycle negative regulation of chromosome separation positive regulation of cellular process positive regulation of spindle checkpoint regulation of signaling negative regulation of mitotic cell cycle phase transition biological regulation negative regulation of cell cycle process positive regulation of cell cycle cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle metaphase/anaphase transition of mitotic cell cycle regulation of cell communication metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition positive regulation of signaling establishment of organelle localization cellular localization mitotic metaphase chromosome alignment metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell establishment of localization establishment of chromosome localization positive regulation of mitotic sister chromatid separation positive regulation of chromosome separation positive regulation of cell division positive regulation of mitotic cytokinesis regulation of cell division regulation of mitotic cytokinesis positive regulation of cytokinesis regulation of cytokinesis regulation of localization regulation of attachment of mitotic spindle microtubules to kinetochore attachment of mitotic spindle microtubules to kinetochore regulation of attachment of spindle microtubules to kinetochore positive regulation of chromosome segregation attachment of spindle microtubules to kinetochore positive regulation of attachment of spindle microtubules to kinetochore positive regulation of attachment of mitotic spindle microtubules to kinetochore regulation of metaphase plate congression	midbody cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen midbody cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoskeleton spindle spindle midzone microtubule cytoskeleton cytoplasm cytosol chromosome, centromeric region chromosome chromosomal region nucleoplasm protein-containing complex chromosome passenger complex microtubule associated complex intercellular bridge chromocenter

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001965	Zinc finger, PHD-type	Domain
A	IPR046341	SET domain superfamily	Homologous Superfamily
A	IPR001214	SET domain	Domain
A	IPR044133	KMT2A, PHD domain 3	Domain
A	IPR003616	Post-SET domain	Domain
A	IPR034732	Extended PHD (ePHD) domain	Domain
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
A	IPR003888	FY-rich, N-terminal	Conserved Site
A	IPR001487	Bromodomain	Domain
A	IPR002857	Zinc finger, CXXC-type	Domain
A	IPR019787	Zinc finger, PHD-finger	Domain
A	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
A	IPR041958	KMT2A, ePHD domain	Domain
A	IPR047219	Histone-lysine N-methyltransferase 2A/2B, SET domain	Domain
A	IPR042025	KMT2A, PHD domain 2	Domain
A	IPR003889	FY-rich, C-terminal	Conserved Site
A	IPR016569	Methyltransferase, trithorax	Family
A	IPR042023	KMT2A, PHD domain 1	Domain
B [auth C]	IPR046466	Borealin, C-terminal	Domain
B [auth C]	IPR018851	Borealin, N-terminal	Domain
B [auth C]	IPR018867	Cell division protein borealin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q03164	myeloid leukemia acute myeloid leukemia acute monocytic leukemia Wiedemann-Steiner syndrome transitional cell carcinoma urinary bladder cancer cancer Chromosome Aberrations acute biphenotypic leukemia leukemia adenocarcinoma chronic monocytic leukemia acute myelomonocytic leukemia M4 tubular adenocarcinoma prostate cancer myeloid leukemia acute myeloid leukemia acute monocytic leukemia Wiedemann-Steiner syndrome transitional cell carcinoma urinary bladder cancer cancer Chromosome Aberrations acute biphenotypic leukemia leukemia adenocarcinoma chronic monocytic leukemia acute myelomonocytic leukemia M4 tubular adenocarcinoma prostate cancer granular cell carcinoma small cell lung carcinoma lymphoid leukemia osteosarcoma Pick disease Cornelia de Lange syndrome cribriform carcinoma of breast gastric neoplasm small cell carcinoma spina bifida hereditary diffuse gastric adenocarcinoma tuberculosis urinary bladder neoplasm Alzheimer disease malignant ependymoma medulloblastoma breast cancer celiac disease ovarian cancer Cornelia de Lange syndrome 1 primitive neuroectodermal tumor psoriasis acute lymphoblastic leukemia glioblastoma hematologic disease intellectual disability subependymal giant cell astrocytoma astrocytic tumor malignant mesothelioma bilineal acute myeloid leukemia metabolic syndrome X Burkitt lymphoma oligodendroglioma childhood acute lymphoblastic leukemia pancreatic ductal adenocarcinoma congenital anemia cribriform carcinoma gastric cancer schizophrenia hepatocellular carcinoma large cell medulloblastoma acute undifferentiated leukemia X-linked mixed deafness with perilymphatic gusher atypical teratoid rhabdoid tumor brain glioma
B [auth C]	Pharos: Q53HL2	adrenal cortex carcinoma breast carcinoma hepatocellular carcinoma lung adenocarcinoma medulloblastoma ovarian carcinoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor endometrial carcinoma invasive ductal breast carcinoma malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis breast cancer adrenal cortex carcinoma breast carcinoma hepatocellular carcinoma lung adenocarcinoma medulloblastoma ovarian carcinoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor endometrial carcinoma invasive ductal breast carcinoma malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis breast cancer glioblastoma large cell medulloblastoma malignant mesothelioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm