Annotations: 7TUF

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth H]	PF07654	e7tufH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B [auth H]	PF07686	e7tufH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
E [auth A]	PF07654	e7tufA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
E [auth A]	PF07686	e7tufA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
A [auth D]	F_UNCLASSIFIED	e7tufD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
A [auth D]	PF07654	e7tufD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
D [auth C]	F_UNCLASSIFIED	e7tufC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth C]	PF07654	e7tufC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
C [auth L]	PF07654	e7tufL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
C [auth L]	PF07686	e7tufL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
F [auth B]	PF07654	e7tufB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
F [auth B]	PF07686	e7tufB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth H], E [auth A]	Heavy Chain	IGHV3	-	tapasin	SAbDab (2024-05-24)
C [auth L], F [auth B]	Light Chain	IGKV4	Kappa	tapasin	SAbDab (2024-05-24)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D], D [auth C]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth H], E [auth A]	PaSta1 Fab heavy chain	-	-	-
A [auth D], D [auth C]	Tapasin	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class I protein complex binding TAP1 binding TAP binding protein binding unfolded protein binding TAP complex binding molecular adaptor activity MHC class I protein binding binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class I protein complex binding TAP1 binding TAP binding protein binding unfolded protein binding TAP complex binding molecular adaptor activity MHC class I protein binding signaling receptor binding MHC protein binding protein folding chaperone TAP2 binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of protein complex stability biological regulation regulation of biological quality regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of protein complex stability biological regulation regulation of biological quality regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum establishment of localization Golgi vesicle transport vesicle-mediated transport peptide stabilization antigen processing and presentation peptide antigen stabilization immune system process antigen processing and presentation of peptide antigen peptide metabolic process antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I peptide antigen assembly with MHC class I protein complex peptide antigen assembly with MHC protein complex MHC class I protein complex assembly MHC protein complex assembly MHC class Ib protein complex assembly	membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane protein-containing complex MHC class I peptide loading complex Tapasin-ERp57 complex membrane protein complex endoplasmic reticulum protein-containing complex lumenal side of endoplasmic reticulum membrane side of membrane lumenal side of membrane intracellular vesicle phagocytic vesicle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane vesicle endocytic vesicle Golgi membrane Golgi apparatus endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment
C [auth L], F [auth B]	PaSta1 Fab kappa light chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D], D [auth C]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth D], D [auth C]	IPR003597	Immunoglobulin C1-set	Domain
A [auth D], D [auth C]	IPR008056	Tapasin	Family
A [auth D], D [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth D], D [auth C]	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth D], D [auth C]	Pharos: O15533	MHC class I deficiency acute myeloid leukemia Bare Lymphocyte Syndrome, Type I endogenous depression juvenile dermatomyositis ovarian cancer schizophrenia astrocytic tumor cervical cancer esophageal adenocarcinoma lung cancer oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma triple-negative breast carcinoma atopic eczema MHC class I deficiency acute myeloid leukemia Bare Lymphocyte Syndrome, Type I endogenous depression juvenile dermatomyositis ovarian cancer schizophrenia astrocytic tumor cervical cancer esophageal adenocarcinoma lung cancer oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma triple-negative breast carcinoma atopic eczema chronic obstructive pulmonary disease glioblastoma malignant ependymoma osteosarcoma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.