7SO8

Crystal structure of Glutathione S-Transferase from Shrimp Litopenaeus vannamei in complex with silver ions and a molecules of Glutathione binding in G-site and H-site

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF14497	e7so8A2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: PF14497	ECOD (1.6)
A	PF02798	e7so8A1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF02798	ECOD (1.6)
B [auth C]	PF14497	e7so8C2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: PF14497	ECOD (1.6)
B [auth C]	PF02798	e7so8C1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF02798	ECOD (1.6)
C [auth E]	PF14497	e7so8E2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: PF14497	ECOD (1.6)
C [auth E]	PF02798	e7so8E1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF02798	ECOD (1.6)
D [auth G]	PF14497	e7so8G2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: PF14497	ECOD (1.6)
D [auth G]	PF02798	e7so8G1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF02798	ECOD (1.6)
E [auth H]	PF14497	e7so8H1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: PF14497	ECOD (1.6)
E [auth H]	PF02798	e7so8H2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF02798	ECOD (1.6)
F	PF14497	e7so8F1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: PF14497	ECOD (1.6)
F	PF02798	e7so8F2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF02798	ECOD (1.6)
G [auth B]	PF14497	e7so8B2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: PF14497	ECOD (1.6)
G [auth B]	PF02798	e7so8B1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF02798	ECOD (1.6)
H [auth D]	PF14497	e7so8D2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Glutathione S-transferase (GST)-C (From Topology)	T: Glutathione S-transferase (GST)-C	F: PF14497	ECOD (1.6)
H [auth D]	PF02798	e7so8D1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF02798	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], C [auth E], D [auth G], E [auth H], A, B [auth C], C [auth E], D [auth G], E [auth H], F, G [auth B], H [auth D]	PF14497	Glutathione S-transferase, C-terminal domain (GST_C_3)	Glutathione S-transferase, C-terminal domain	This domain is closely related to Pfam:PF00043.	Domain
A, B [auth C], C [auth E], D [auth G], E [auth H], A, B [auth C], C [auth E], D [auth G], E [auth H], F, G [auth B], H [auth D]	PF02798	Glutathione S-transferase, N-terminal domain (GST_N)	Glutathione S-transferase, N-terminal domain	Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but not GSTs: S-crystallins from squid (similarity to GST previously noted); eukaryotic elongation factors 1-gamma (not known to have GST activity a ...	Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but not GSTs: S-crystallins from squid (similarity to GST previously noted); eukaryotic elongation factors 1-gamma (not known to have GST activity and similarity not previously recognised); HSP26 family of stress-related proteins including auxin-regulated proteins in plants and stringent starvation proteins in E. coli (not known to have GST activity and similarity not previously recognised). The glutathione molecule binds in a cleft between the N- and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth E], D [auth G], E [auth H], A, B [auth C], C [auth E], D [auth G], E [auth H], F, G [auth B], H [auth D]	Glutathione transferase	glutathione transferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth E], D [auth G], E [auth H], A, B [auth C], C [auth E], D [auth G], E [auth H], F, G [auth B], H [auth D]	IPR003081	Glutathione S-transferase, Mu class	Family
A, B [auth C], C [auth E], D [auth G], E [auth H], A, B [auth C], C [auth E], D [auth G], E [auth H], F, G [auth B], H [auth D]	IPR004046	Glutathione S-transferase, C-terminal	Domain
A, B [auth C], C [auth E], D [auth G], E [auth H], A, B [auth C], C [auth E], D [auth G], E [auth H], F, G [auth B], H [auth D]	IPR010987	Glutathione S-transferase, C-terminal-like	Domain
A, B [auth C], C [auth E], D [auth G], E [auth H], A, B [auth C], C [auth E], D [auth G], E [auth H], F, G [auth B], H [auth D]	IPR036282	Glutathione S-transferase, C-terminal domain superfamily	Homologous Superfamily
A, B [auth C], C [auth E], D [auth G], E [auth H], A, B [auth C], C [auth E], D [auth G], E [auth H], F, G [auth B], H [auth D]	IPR004045	Glutathione S-transferase, N-terminal	Domain
A, B [auth C], C [auth E], D [auth G], E [auth H], A, B [auth C], C [auth E], D [auth G], E [auth H], F, G [auth B], H [auth D]	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.