7PGB

NaV_Ae1/Sp1CTD_pore-SAT09 complex

External Resource: Annotation

Domain Annotation: ECOD Classification
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth H]	PF07654	e7pgbH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
A [auth H]	PF07686	e7pgbH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
AA [auth i]	PF07654	e7pgbi2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
AA [auth i]	PF07686	e7pgbi1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
D [auth A]	PF07654	e7pgbA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
D [auth A]	PF07686	e7pgbA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
G [auth R]	PF07654	e7pgbR1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
G [auth R]	PF07686	e7pgbR2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
J [auth U]	PF07654	e7pgbU1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
J [auth U]	PF07686	e7pgbU2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
M [auth X]	PF07654	e7pgbX1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
M [auth X]	PF07686	e7pgbX2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
P [auth a]	PF07654	e7pgba1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
P [auth a]	PF07686	e7pgba2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
S [auth m]	PF07654	e7pgbm2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
S [auth m]	PF07686	e7pgbm1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
V [auth p]	PF07654	e7pgbp1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
V [auth p]	PF07686	e7pgbp2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
Y [auth f]	PF07654	e7pgbf1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
Y [auth f]	PF07686	e7pgbf2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
B [auth L]	PF07654	e7pgbL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B [auth L]	PF07686	e7pgbL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
BA [auth k]	PF07654	e7pgbk1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
BA [auth k]	PF07686	e7pgbk2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
E [auth B]	PF07654	e7pgbB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
E [auth B]	PF07686	e7pgbB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
H [auth S]	PF07654	e7pgbS1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
H [auth S]	PF07686	e7pgbS2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
K [auth V]	PF07654	e7pgbV1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
K [auth V]	PF07686	e7pgbV2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
N [auth Y]	PF07654	e7pgbY1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
N [auth Y]	PF07686	e7pgbY2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
Q [auth b]	PF07654	e7pgbb1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
Q [auth b]	PF07686	e7pgbb2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
W [auth q]	PF07654	e7pgbq1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
W [auth q]	PF07686	e7pgbq2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
Z [auth g]	PF07654	e7pgbg1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
Z [auth g]	PF07686	e7pgbg2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
T [auth n]	PF07654	e7pgbn2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
T [auth n]	PF07686	e7pgbn1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
C [auth c]	PF00520	e7pgbc1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
CA [auth h]	PF00520	e7pgbh1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
F [auth C]	PF00520	e7pgbC1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
I [auth T]	PF00520	e7pgbT1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
L [auth W]	PF00520	e7pgbW1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
O [auth Z]	PF00520	e7pgbZ1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
R [auth d]	PF00520	e7pgbd1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
U [auth l]	PF00520	e7pgbl1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
X [auth o]	PF00520	e7pgbo1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)
DA [auth e]	PF00520	e7pgbe1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: PF00520	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth H], AA [auth i], D [auth A], G [auth R], J [auth U], A [auth H], AA [auth i], D [auth A], G [auth R], J [auth U], M [auth X], P [auth a], S [auth m], V [auth p], Y [auth f]	Heavy Chain	IGHV3	-	ion transport protein,voltage-gated sodium channel	SAbDab (2024-05-24)
B [auth L], BA [auth k], E [auth B], H [auth S], K [auth V], B [auth L], BA [auth k], E [auth B], H [auth S], K [auth V], N [auth Y], Q [auth b], T [auth n], W [auth q], Z [auth g]	Light Chain	IGKV1	Kappa	ion transport protein,voltage-gated sodium channel	SAbDab (2024-05-24)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], L [auth W], O [auth Z], R [auth d], U [auth l], X [auth o]	PF00520	Ion transport protein (Ion_trans)	Ion transport protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H], AA [auth i], D [auth A], G [auth R], J [auth U], A [auth H], AA [auth i], D [auth A], G [auth R], J [auth U], M [auth X], P [auth a], S [auth m], V [auth p], Y [auth f]	SAT09 fab fragment, heavy chain	-	-	-
B [auth L], BA [auth k], E [auth B], H [auth S], K [auth V], B [auth L], BA [auth k], E [auth B], H [auth S], K [auth V], N [auth Y], Q [auth b], T [auth n], W [auth q], Z [auth g]	SAT09 fab fragment, light chain	-	-	-
C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], L [auth W], O [auth Z], R [auth d], U [auth l], X [auth o]	Ion transport protein,Voltage-gated sodium channel	monoatomic cation transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding monoatomic cation transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	-	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], L [auth W], O [auth Z], R [auth d], U [auth l], X [auth o]	IPR005821	Ion transport domain	Domain
C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], L [auth W], O [auth Z], R [auth d], U [auth l], X [auth o]	IPR043203	Voltage-gated cation channel calcium and sodium	Family
C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], L [auth W], O [auth Z], R [auth d], U [auth l], X [auth o]	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily
C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], L [auth W], O [auth Z], R [auth d], U [auth l], X [auth o]	IPR005821	Ion transport domain	Domain
C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], L [auth W], O [auth Z], R [auth d], U [auth l], X [auth o]	IPR043203	Voltage-gated cation channel calcium and sodium	Family
C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], L [auth W], O [auth Z], R [auth d], U [auth l], X [auth o]	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T] C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], L [auth W], O [auth Z], R [auth d], U [auth l], X [auth o]	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Voltage-gated calcium and sodium channels

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T] C [auth c], CA [auth h], DA [auth e], F [auth C], I [auth T], L [auth W], O [auth Z], R [auth d], U [auth l], X [auth o]	PDBTM	Annotated as membrane protein by PDBTM