7CXD

Xray structure of rat Galectin-3 CRD in complex with TD-139 belonging to P121 space group

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8104291	3000120	SCOP2B (2022-06-29)
C [auth D]	SCOP2 Family	Galectin (animal S-lectin)	8104290	4002674	SCOP2 (2022-06-29)
C [auth D]	SCOP2 Superfamily	Concanavalin A-like lectins/glucanases	8104291	3000120	SCOP2 (2022-06-29)
D [auth E]	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8104291	3000120	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8104291	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF00337	e7cxdB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
C [auth D]	PF00337	e7cxdD1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
D [auth E]	PF00337	e7cxdE1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)
A	PF00337	e7cxdA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: PF00337	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C [auth D], D [auth E]	PF00337	Galactoside-binding lectin (Gal-bind_lectin)	Galactoside-binding lectin	This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (Swiss:Q05315, EC:3.1.1.5).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C [auth D], D [auth E]	Galectin-3	oligosaccharide binding binding disaccharide binding carbohydrate binding extracellular matrix binding protein binding laminin binding monosaccharide binding small molecule binding protein phosphatase binding phosphatase binding enzyme binding molecular transducer activity signaling receptor activity oligosaccharide binding binding disaccharide binding carbohydrate binding extracellular matrix binding protein binding laminin binding monosaccharide binding small molecule binding protein phosphatase binding phosphatase binding enzyme binding molecular transducer activity signaling receptor activity advanced glycation end-product receptor activity protein-containing complex binding signaling receptor binding immunoglobulin receptor binding Fc-gamma receptor I complex binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity IgE binding immunoglobulin binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity chemoattractant activity signaling receptor activator activity	multicellular organismal process regulation of cellular process regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation T cell activation lymphocyte proliferation regulation of multicellular organismal process regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation multicellular organismal process regulation of cellular process regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation T cell activation lymphocyte proliferation regulation of multicellular organismal process regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation regulation of biological process cell population proliferation biological regulation cell activation regulation of T cell activation regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation cellular process regulation of lymphocyte activation developmental process multicellular organism development skeletal system development anatomical structure development system development positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane positive regulation of cellular component organization regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component organization cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly cellular component organization or biogenesis extracellular matrix organization extracellular structure organization external encapsulating structure organization cell chemotaxis cellular response to stimulus chemotaxis response to stimulus neutrophil chemotaxis response to external stimulus neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis granulocyte chemotaxis response to chemical myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion mononuclear cell migration biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus extrinsic apoptotic signaling pathway via death domain receptors signaling regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway cell communication signal transduction regulation of signaling cell surface receptor signaling pathway regulation of apoptotic process cell death regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway positive chemotaxis epithelium development cellular developmental process cell differentiation tissue development epithelial cell differentiation cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process macromolecule metabolic process RNA processing RNA splicing immune response-regulating cell surface receptor signaling pathway negative regulation of signaling negative regulation of biological process regulation of antigen receptor-mediated signaling pathway negative regulation of antigen receptor-mediated signaling pathway negative regulation of cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response negative regulation of cellular process positive regulation of immune system process immune response-activating cell surface receptor signaling pathway negative regulation of response to stimulus regulation of T cell receptor signaling pathway T cell receptor signaling pathway negative regulation of signal transduction negative regulation of T cell receptor signaling pathway negative regulation of immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response immunological synapse formation negative regulation of immunological synapse formation regulation of immunological synapse formation negative regulation of lymphocyte activation cell recognition cell-cell recognition negative regulation of cell activation negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of calcium ion import regulation of calcium ion transport positive regulation of calcium ion transport positive regulation of calcium ion import transport regulation of transport regulation of monoatomic ion transport establishment of localization calcium ion transport metal ion transport positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport import into cell negative regulation of cellular component organization negative regulation of transport negative regulation of endocytosis regulation of vesicle-mediated transport vesicle-mediated transport endocytosis regulation of endocytosis eosinophil chemotaxis eosinophil migration negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of programmed cell death negative regulation of apoptotic process monoamine transport nitrogen compound transport organic hydroxy compound transport positive regulation of secretion by cell secretion by cell regulation of secretion by cell positive regulation of secretion signal release serotonin secretion positive regulation of serotonin secretion secretion organic substance transport cell-cell signaling export from cell serotonin transport regulation of serotonin secretion regulation of secretion response to organic substance response to oxygen-containing compound response to quercetin response to flavonoid negative regulation of cell population proliferation negative regulation of cell proliferation in bone marrow cell proliferation in bone marrow regulation of cell proliferation in bone marrow positive regulation of cell population proliferation monocyte chemotaxis positive regulation of locomotion regulation of cell motility positive regulation of cell migration positive regulation of cell motility positive regulation of mononuclear cell migration regulation of cell migration regulation of mononuclear cell migration regulation of leukocyte migration positive regulation of leukocyte migration regulation of locomotion regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process leukocyte apoptotic process lymphocyte apoptotic process regulation of T cell apoptotic process T cell apoptotic process macrophage chemotaxis macrophage migration regulation of immune effector process cell activation involved in immune response negative regulation of cell adhesion T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of immune response negative regulation of immune effector process immune effector process negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion cell adhesion cell-cell adhesion T cell activation involved in immune response leukocyte activation involved in immune response regulation of cell-cell adhesion lymphocyte activation involved in immune response regulation of cell adhesion regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	cell periphery plasma membrane membrane cellular anatomical entity cornified envelope cell surface external side of plasma membrane side of membrane intracellular anatomical structure cytoplasm extracellular region extracellular space membrane-bounded organelle mitochondrial membrane cell periphery plasma membrane membrane cellular anatomical entity cornified envelope cell surface external side of plasma membrane side of membrane intracellular anatomical structure cytoplasm extracellular region extracellular space membrane-bounded organelle mitochondrial membrane organelle inner membrane mitochondrion intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle organelle membrane glial cell projection cell projection plasma membrane bounded cell projection extracellular matrix external encapsulating structure immunological synapse protein-containing complex nucleus nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C [auth D], D [auth E]	IPR044156	Galectin-like	Family
A, B, C [auth D], D [auth E]	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B, C [auth D], D [auth E]	IPR001079	Galectin, carbohydrate recognition domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.