Annotations: 7BQI

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02759	e7bqiA1	A: alpha arrays	X: RUN domain (From Topology)	H: RUN domain (From Topology)	T: RUN domain	F: PF02759	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02759	RUN domain (RUN)	RUN domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	FYVE and coiled-coil domain-containing protein 1	cation binding ion binding binding metal ion binding small molecule binding	establishment of organelle localization vesicle cytoskeletal trafficking vesicle localization cellular localization organelle transport along microtubule transport establishment of vesicle localization intracellular transport establishment of localization plus-end-directed organelle transport along microtubule vesicle transport along microtubule localization plus-end-directed vesicle transport along microtubule organelle localization establishment of localization in cell establishment of organelle localization vesicle cytoskeletal trafficking vesicle localization cellular localization organelle transport along microtubule transport establishment of vesicle localization intracellular transport establishment of localization plus-end-directed organelle transport along microtubule vesicle transport along microtubule localization plus-end-directed vesicle transport along microtubule organelle localization establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport cellular process microtubule-based movement microtubule-based process positive regulation of organelle organization catabolic process regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization regulation of autophagosome maturation macroautophagy autophagy positive regulation of biological process protein-containing complex disassembly positive regulation of cellular metabolic process regulation of autophagy regulation of protein-containing complex disassembly cellular catabolic process cellular component organization positive regulation of metabolic process autophagosome maturation cellular component organization or biogenesis positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of protein-containing complex disassembly positive regulation of cellular process cellular component disassembly positive regulation of autophagy regulation of biological process protein-containing complex organization cellular metabolic process biological regulation regulation of cellular metabolic process regulation of catabolic process positive regulation of autophagosome maturation regulation of organelle organization positive regulation of catabolic process organelle organization regulation of macroautophagy regulation of cellular catabolic process positive regulation of cellular catabolic process metabolic process regulation of metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle vacuole autophagosome cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane Golgi apparatus endomembrane system endosome intracellular vesicle membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle vacuole autophagosome cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane Golgi apparatus endomembrane system endosome intracellular vesicle cytoplasmic vesicle late endosome vesicle lytic vacuole lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR037213	RUN domain superfamily	Homologous Superfamily
A	IPR004012	RUN domain	Domain
A	IPR017455	Zinc finger, FYVE-related	Domain
A	IPR009038	GOLD domain	Domain
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR047336	FYCO1, RUN domain	Domain
A	IPR000306	FYVE zinc finger	Domain
A	IPR036598	GOLD domain superfamily	Homologous Superfamily
A	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
A	IPR047337	FYCO1, FYVE domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9BQS8	cataract 18 cataract breast cancer Cataract, autosomal recessive congenital 2 intellectual disability malignant colon neoplasm myopathy osteosarcoma subependymal giant cell astrocytoma invasive ductal breast carcinoma malignant glioma nuclear cataract ovarian cancer tuberculosis glioblastoma cataract 18 cataract breast cancer Cataract, autosomal recessive congenital 2 intellectual disability malignant colon neoplasm myopathy osteosarcoma subependymal giant cell astrocytoma invasive ductal breast carcinoma malignant glioma nuclear cataract ovarian cancer tuberculosis glioblastoma lung cancer malignant mesothelioma pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.