Annotations: 6ZSS

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6zssA1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ly6/PLAUR domain-containing protein 1	protein binding binding signaling receptor binding acetylcholine receptor binding neurotransmitter receptor regulator activity acetylcholine receptor regulator activity molecular function inhibitor activity acetylcholine receptor inhibitor activity molecular function regulator activity signaling receptor inhibitor activity signaling receptor regulator activity	protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization negative regulation of biological process negative regulation of protein localization to plasma membrane localization cellular macromolecule localization negative regulation of cellular process regulation of protein localization to membrane negative regulation of protein localization regulation of biological process protein localization to cell periphery protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization negative regulation of biological process negative regulation of protein localization to plasma membrane localization cellular macromolecule localization negative regulation of cellular process regulation of protein localization to membrane negative regulation of protein localization regulation of biological process protein localization to cell periphery protein localization to plasma membrane biological regulation localization within membrane regulation of protein localization to cell periphery protein localization to membrane negative regulation of protein localization to membrane regulation of cellular localization macromolecule localization negative regulation of protein localization to cell periphery cellular process regulation of protein localization to plasma membrane behavioral defense response behavior multicellular organismal process fear response behavioral fear response response to stimulus defense response response to stress multicellular organismal response to stress response to chemical response to nicotine cellular response to nitrogen compound cellular response to stimulus cellular response to acetylcholine response to organic substance signaling response to oxygen-containing compound cell-cell signaling response to nitrogen compound acetylcholine receptor signaling pathway postsynaptic signal transduction cellular response to oxygen-containing compound cell communication cellular response to chemical stimulus synaptic signaling response to acetylcholine signal transduction trans-synaptic signaling chemical synaptic transmission anterograde trans-synaptic signaling synaptic transmission, cholinergic	membrane cellular anatomical entity side of membrane extracellular region synapse cell junction cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR045860	Snake toxin-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8N2G4	astrocytic tumor cystic fibrosis lung carcinoma malignant mesothelioma oligodendroglioma pituitary cancer breast cancer glioblastoma malignant ependymoma medulloblastoma ovarian cancer psoriasis cutaneous lupus erythematosus lung adenocarcinoma malignant glioma astrocytic tumor cystic fibrosis lung carcinoma malignant mesothelioma oligodendroglioma pituitary cancer breast cancer glioblastoma malignant ependymoma medulloblastoma ovarian cancer psoriasis cutaneous lupus erythematosus lung adenocarcinoma malignant glioma non-small cell lung carcinoma pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.