This entry represents the N-terminal domain of bacterial proteins, such as the dermonecreotic toxin (ToxA) from Pasteurella multocida, an osteolytic toxin that induces bone resorption. It is a potent mitogen. This toxin is associated with the severe ...
This entry represents the N-terminal domain of bacterial proteins, such as the dermonecreotic toxin (ToxA) from Pasteurella multocida, an osteolytic toxin that induces bone resorption. It is a potent mitogen. This toxin is associated with the severe progressive form of the atrophic rhinitis a major respiratory disease in pigs. This domain contributes to the membrane localisation of its C-terminal domains [1].
Rho-activating domain of cytotoxic necrotizing factor
This family consists of several bacterial cytotoxic necrotizing factor proteins as well as related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) causes necrosis of rabbit skin and re-organisation of the acti ...
This family consists of several bacterial cytotoxic necrotizing factor proteins as well as related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) causes necrosis of rabbit skin and re-organisation of the actin cytoskeleton in cultured cells [1]. Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho. DNT is an A-B toxin which is composed of an N-terminal receptor-binding (B) domain and a C-terminal enzymatically active (A) domain [2].
