Annotations: 6X39

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6x39a1	All beta proteins	Immunoglobulin-like beta-sandwich	Fibronectin type III	automated matches	automated matches	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d6x39a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00041	e6x39A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00041	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00041	Fibronectin type III domain (fn3)	Fibronectin type III domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Receptor-type tyrosine-protein phosphatase F	phosphoric ester hydrolase activity molecular transducer activity catalytic activity, acting on a protein phosphatase activity signaling receptor activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity transmembrane receptor protein phosphatase activity transmembrane signaling receptor activity transmembrane receptor protein tyrosine phosphatase activity catalytic activity protein binding phosphoric ester hydrolase activity molecular transducer activity catalytic activity, acting on a protein phosphatase activity signaling receptor activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity transmembrane receptor protein phosphatase activity transmembrane signaling receptor activity transmembrane receptor protein tyrosine phosphatase activity catalytic activity protein binding binding signaling receptor binding insulin receptor binding glycosaminoglycan binding proteoglycan binding chondroitin sulfate proteoglycan binding carbohydrate derivative binding sulfur compound binding protein-containing complex binding protein tyrosine kinase binding kinase binding receptor tyrosine kinase binding enzyme binding protein kinase binding cell adhesion molecule binding ion binding anion binding phosphate ion binding small molecule binding heparin binding	biological regulation regulation of synapse structure or activity regulation of biological quality regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death biological regulation regulation of synapse structure or activity regulation of biological quality regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process cellular response to stimulus cellular response to growth factor stimulus response to stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction negative regulation of cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication cell communication cellular response to endogenous stimulus neurotrophin signaling pathway negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus neurotrophin TRK receptor signaling pathway negative regulation of signal transduction regulation of neurotrophin TRK receptor signaling pathway regulation of response to stimulus negative regulation of neurotrophin TRK receptor signaling pathway regulation of cell communication response to growth factor neuron apoptotic process positive regulation of neuron apoptotic process regulation of neuron apoptotic process negative regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway negative regulation of epidermal growth factor receptor signaling pathway ERBB signaling pathway cell migration cell motility cellular response to nitrogen compound response to organic substance response to peptide hormone insulin receptor signaling pathway regulation of cellular response to insulin stimulus response to hormone cellular response to organic substance cellular response to hormone stimulus response to organonitrogen compound regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus negative regulation of cellular response to insulin stimulus cellular response to organonitrogen compound negative regulation of insulin receptor signaling pathway response to chemical response to insulin cellular response to insulin stimulus developmental process multicellular organism development multicellular organismal process anatomical structure development nervous system development system development cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules regulation of cellular component organization postsynapse organization regulation of postsynapse organization cellular component organization regulation of synapse organization cell junction organization synapse organization cellular component organization or biogenesis cellular developmental process cell projection organization cell development neuron projection development regeneration neuron projection regeneration neurogenesis neuron differentiation cellular response to stress cell differentiation response to stress plasma membrane bounded cell projection organization generation of neurons neuron development synaptic membrane adhesion response to cytokine cytokine-mediated signaling pathway cellular response to cytokine stimulus regulation of cytokine-mediated signaling pathway regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus negative regulation of cytokine-mediated signaling pathway negative regulation of receptor binding regulation of protein binding regulation of molecular function regulation of receptor binding negative regulation of protein binding regulation of binding negative regulation of binding negative regulation of molecular function negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation protein dephosphorylation organonitrogen compound metabolic process dephosphorylation cellular metabolic process primary metabolic process organic substance metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process peptidyl-tyrosine dephosphorylation regulation of neuron projection development regulation of cell projection organization regulation of plasma membrane bounded cell projection organization regulation of developmental process regulation of response to external stimulus regulation of cellular response to stress response to axon injury regulation of response to wounding axon regeneration regulation of response to stress response to wounding regulation of axon regeneration response to external stimulus axon development regulation of neuron projection regeneration negative regulation of cellular component organization negative regulation of cell projection organization positive regulation of nervous system development regulation of cell differentiation regulation of neurogenesis regulation of cell morphogenesis regulation of cell development positive regulation of developmental process cell projection morphogenesis neuron projection morphogenesis regulation of dendrite morphogenesis positive regulation of cell projection organization positive regulation of cell development positive regulation of cell morphogenesis regulation of dendrite development positive regulation of multicellular organismal process positive regulation of cellular component organization plasma membrane bounded cell projection morphogenesis cell morphogenesis regulation of nervous system development positive regulation of cell differentiation dendrite development positive regulation of neurogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of dendrite morphogenesis dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region cell projection neuron projection plasma membrane bounded cell projection somatodendritic compartment cell body neuronal cell body growth cone axon distal axon site of polarized growth membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle cytoplasm vesicle excitatory synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR003599	Immunoglobulin subtype	Domain
A	IPR003598	Immunoglobulin subtype 2	Domain
A	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
A	IPR013098	Immunoglobulin I-set	Domain
A	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A	IPR003961	Fibronectin type III	Domain
A	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain	Domain
A	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.