6W9N

Solution structure of the FYVE domain of ALFY

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6w9na1	Small proteins	FYVE/PHD zinc finger	FYVE/PHD zinc finger	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d6w9na2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01363	e6w9nA1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: FYVE/PHD zinc finger	F: PF01363	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01363	FYVE zinc finger (FYVE)	FYVE zinc finger	The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions [1]. The FYVE finger has eight potential zinc coordinating cysteine positions. Man ...	The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions [1]. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. We have included members which do not conserve these histidine residues but are clearly related.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	WD repeat and FYVE domain-containing protein 3	1-phosphatidylinositol binding binding phospholipid binding lipid binding phosphatidylinositol binding cation binding ion binding metal ion binding small molecule binding	cellular catabolic process catabolic process macroautophagy cellular metabolic process autophagy aggrephagy cellular process metabolic process process utilizing autophagic mechanism	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle somatodendritic compartment cell body perikaryon neuronal cell body membrane organelle envelope nuclear envelope endomembrane system nuclear membrane organelle membrane cytoplasm cytosol cell periphery plasma membrane inclusion body nucleoplasm vacuole autophagosome vacuolar membrane autophagosome membrane bounding membrane of organelle axon cell projection neuron projection plasma membrane bounded cell projection nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR017455	Zinc finger, FYVE-related	Domain
A	IPR019775	WD40 repeat, conserved site	Conserved Site
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR000306	FYVE zinc finger	Domain
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A	IPR000409	BEACH domain	Domain
A	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A	IPR001680	WD40 repeat	Repeat
A	IPR036372	BEACH domain superfamily	Homologous Superfamily
A	IPR023362	PH-BEACH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8IZQ1	microcephaly 18, primary, autosomal dominant Neurodevelopmental Disorders subependymal giant cell astrocytoma amyotrophic lateral sclerosis intellectual disability malignant ependymoma MALT lymphoma osteosarcoma psoriasis atypical teratoid rhabdoid tumor juvenile dermatomyositis malignant glioma medulloblastoma myopathy ovarian cancer microcephaly 18, primary, autosomal dominant Neurodevelopmental Disorders subependymal giant cell astrocytoma amyotrophic lateral sclerosis intellectual disability malignant ependymoma MALT lymphoma osteosarcoma psoriasis atypical teratoid rhabdoid tumor juvenile dermatomyositis malignant glioma medulloblastoma myopathy ovarian cancer Sjogren syndrome glioblastoma large cell medulloblastoma malignant mesothelioma microcephaly

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.