6VME

Human ESCRT-I heterotetramer headpiece

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
T [auth U]	d6vmeu_	All alpha proteins	Long alpha-hairpin	Endosomal sorting complex assembly domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
V [auth W]	d6vmew_	All alpha proteins	Long alpha-hairpin	Endosomal sorting complex assembly domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
W [auth X]	d6vmex_	All alpha proteins	Long alpha-hairpin	Endosomal sorting complex assembly domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
X [auth Y]	d6vmey_	All alpha proteins	Long alpha-hairpin	Endosomal sorting complex assembly domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth E]	d6vmee_	All alpha proteins	Long alpha-hairpin	Endosomal sorting complex assembly domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
U [auth V]	d6vmev_	All alpha proteins	Long alpha-hairpin	Endosomal sorting complex assembly domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
H [auth I]	PF09454	e6vmeI1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF09454	ECOD (1.6)
A [auth B]	PF09454	e6vmeB1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF09454	ECOD (1.6)
E [auth F]	PF09454	e6vmeF1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF09454	ECOD (1.6)
F [auth G]	PF09454	e6vmeG1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF09454	ECOD (1.6)
G [auth H]	PF09454	e6vmeH1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF09454	ECOD (1.6)
I [auth J]	PF09454	e6vmeJ1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF09454	ECOD (1.6)
K [auth L]	PF07200	e6vmeL1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF07200	ECOD (1.6)
M [auth N]	PF07200	e6vmeN1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF07200	ECOD (1.6)
B [auth C]	PF07200	e6vmeC1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF07200	ECOD (1.6)
J [auth K]	PF07200	e6vmeK1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF07200	ECOD (1.6)
L [auth M]	PF07200	e6vmeM1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF07200	ECOD (1.6)
N [auth O]	PF07200	e6vmeO1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF07200	ECOD (1.6)
T [auth U]	PF03997	e6vmeU1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF03997	ECOD (1.6)
V [auth W]	PF03997	e6vmeW1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF03997	ECOD (1.6)
W [auth X]	PF03997	e6vmeX1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF03997	ECOD (1.6)
X [auth Y]	PF03997	e6vmeY1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF03997	ECOD (1.6)
D [auth E]	PF03997	e6vmeE1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF03997	ECOD (1.6)
U [auth V]	PF03997	e6vmeV1	A: alpha bundles	X: Long alpha-hairpin	H: Endosomal sorting complex assembly domains (From Topology)	T: Endosomal sorting complex assembly domains	F: PF03997	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
H [auth I]	6.10.140.820	Special	Helix non-globular	Helix Hairpins		CATH (utative)
A [auth B]	6.10.140.820	Special	Helix non-globular	Helix Hairpins		CATH (utative)
E [auth F]	6.10.140.820	Special	Helix non-globular	Helix Hairpins		CATH (utative)
F [auth G]	6.10.140.820	Special	Helix non-globular	Helix Hairpins		CATH (utative)
G [auth H]	6.10.140.820	Special	Helix non-globular	Helix Hairpins		CATH (utative)
I [auth J]	6.10.140.820	Special	Helix non-globular	Helix Hairpins		CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J]	PF09454	Vps23 core domain (Vps23_core)	Vps23 core domain	ESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. The core domain of the Vps23 subunit of the heterotrimeric ESCRT-I complex is a helical hairpin sandwiched in a fan-like formation between two other helical ...	ESCRT complexes form the main machinery driving protein sorting from endosomes to lysosomes. The core domain of the Vps23 subunit of the heterotrimeric ESCRT-I complex is a helical hairpin sandwiched in a fan-like formation between two other helical hairpins from Vps28 (Pfam:PF03997) and Vps37. Vps23 gives ESCRT-I complex its stability [1].	Domain
B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], N [auth O]	PF07200	Modifier of rudimentary (Mod(r)) protein (Mod_r)	Modifier of rudimentary (Mod(r)) protein	This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acid ...	This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic [1], and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homologue of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors [2].	Domain
C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], S [auth T]	PF10240	Multivesicular body subunit 12 (DUF2464)	Multivesicular body subunit 12	-	Family
D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	PF03997	VPS28 protein (VPS28)	VPS28 protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J]	Tumor susceptibility gene 101 protein	DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding ubiquitin binding ubiquitin-like protein binding transcription corepressor activity transcription regulator activity transcription coregulator activity DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding ubiquitin binding ubiquitin-like protein binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity identical protein binding protein homodimerization activity protein dimerization activity calcium-dependent protein binding virion binding	localization transport extracellular transport establishment of localization organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process cellular component disassembly catabolic process localization transport extracellular transport establishment of localization organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process cellular component disassembly catabolic process macroautophagy protein-containing complex organization cellular metabolic process autophagy protein-containing complex disassembly cellular catabolic process cellular component organization autophagosome maturation cellular process cellular component organization or biogenesis process utilizing autophagic mechanism regulation of biological process positive regulation of viral life cycle positive regulation of viral process biological regulation positive regulation of biological process viral budding viral budding via host ESCRT complex viral life cycle regulation of viral budding via host ESCRT complex virion assembly regulation of viral process regulation of viral life cycle viral process positive regulation of viral budding via host ESCRT complex cellular response to stimulus regulation of cellular process response to stimulus negative regulation of protein tyrosine kinase activity regulation of catalytic activity negative regulation of biological process negative regulation of catalytic activity regulation of signal transduction regulation of transferase activity negative regulation of cellular metabolic process cell surface receptor protein tyrosine kinase signaling pathway regulation of primary metabolic process cell communication negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process negative regulation of protein modification process epidermal growth factor receptor signaling pathway signal transduction phosphorus metabolic process negative regulation of protein metabolic process regulation of ERBB signaling pathway protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of molecular function regulation of protein tyrosine kinase activity regulation of kinase activity regulation of response to stimulus negative regulation of protein phosphorylation negative regulation of epidermal growth factor receptor signaling pathway ERBB signaling pathway regulation of phosphorus metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation signaling negative regulation of signaling regulation of epidermal growth factor-activated receptor activity regulation of signaling receptor activity negative regulation of ERBB signaling pathway negative regulation of phosphate metabolic process peptidyl-tyrosine modification negative regulation of cell communication regulation of epidermal growth factor receptor signaling pathway negative regulation of cellular process enzyme-linked receptor protein signaling pathway negative regulation of macromolecule metabolic process negative regulation of peptidyl-tyrosine phosphorylation regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of peptidyl-tyrosine phosphorylation negative regulation of molecular function regulation of macromolecule metabolic process regulation of protein kinase activity negative regulation of protein kinase activity negative regulation of epidermal growth factor-activated receptor activity negative regulation of signal transduction negative regulation of phosphorus metabolic process regulation of cell communication regulation of phosphorylation negative regulation of phosphorylation peptidyl-tyrosine phosphorylation negative regulation of signaling receptor activity cell division organonitrogen compound catabolic process proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-dependent protein catabolic process organic substance catabolic process regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth protein localization import into cell regulation of localization ubiquitin-dependent endocytosis establishment of protein localization cellular localization nitrogen compound transport positive regulation of cellular component organization regulation of protein localization positive regulation of establishment of protein localization vesicle-mediated transport positive regulation of protein transport positive regulation of endocytosis cellular macromolecule localization regulation of ubiquitin-dependent endocytosis positive regulation of cellular process regulation of endocytosis regulation of transport organic substance transport regulation of establishment of protein localization regulation of protein transport regulation of vesicle-mediated transport establishment of protein localization to organelle positive regulation of transport protein transport regulation of cellular localization macromolecule localization protein localization to organelle positive regulation of ubiquitin-dependent endocytosis positive regulation of protein localization endocytosis regulation of MAP kinase activity regulation of protein serine/threonine kinase activity organelle assembly regulation of extracellular exosome assembly regulation of cellular component biogenesis extracellular exosome biogenesis regulation of organelle organization cellular component biogenesis vesicle organization organelle organization cellular component assembly extracellular vesicle biogenesis regulation of organelle assembly extracellular exosome assembly negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process developmental process epithelium development epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation anatomical structure development endosome to lysosome transport intracellular transport lysosomal transport establishment of localization in cell vacuolar transport multivesicular body assembly multivesicular body organization endosome organization endomembrane system organization cell cycle membrane organization membrane fission negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation exit from host cell biological process involved in interspecies interaction between organisms viral release from host cell biological process involved in interaction with host biological process involved in symbiotic interaction establishment of protein localization to vacuole late endosome to vacuole transport late endosome to vacuole transport via multivesicular body sorting pathway endosome transport via multivesicular body sorting pathway protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein localization to vacuole endosomal transport multivesicular body sorting pathway intracellular protein transport exosomal secretion establishment of organelle localization positive regulation of secretion by cell positive regulation of exosomal secretion positive regulation of exocytosis secretion by cell regulation of secretion by cell positive regulation of secretion organelle localization vesicle localization positive regulation of cellular component biogenesis secretion regulation of exosomal secretion establishment of vesicle localization export from cell regulation of secretion exocytosis regulation of exocytosis regulation of cell cycle	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol endosome membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol endosome membrane protein-containing complex ESCRT complex endosome membrane intracellular vesicle membrane protein complex intracellular membrane-bounded organelle ESCRT I complex endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle membrane late endosome membrane late endosome nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton cell periphery plasma membrane multivesicular body early endosome early endosome membrane Flemming body midbody
B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], N [auth O]	Vacuolar protein sorting-associated protein 37B	calcium-dependent protein binding protein binding binding	membrane organization cellular component organization membrane fission cellular process cellular component organization or biogenesis cellular catabolic process catabolic process macroautophagy cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism protein localization establishment of protein localization membrane organization cellular component organization membrane fission cellular process cellular component organization or biogenesis cellular catabolic process catabolic process macroautophagy cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism protein localization establishment of protein localization cellular localization nitrogen compound transport transport protein targeting organic substance transport establishment of protein localization to vacuole protein localization to vacuole intracellular transport establishment of localization localization establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell vacuolar transport protein targeting to vacuole intracellular protein transport regulation of biological process positive regulation of viral life cycle positive regulation of viral process biological regulation positive regulation of biological process viral budding viral budding via host ESCRT complex viral life cycle regulation of viral budding via host ESCRT complex virion assembly regulation of viral process regulation of viral life cycle viral process positive regulation of viral budding via host ESCRT complex organelle assembly multivesicular body assembly vesicle organization cellular component biogenesis organelle organization cellular component assembly multivesicular body organization endosome organization endomembrane system organization exit from host cell biological process involved in interspecies interaction between organisms viral release from host cell biological process involved in interaction with host biological process involved in symbiotic interaction proteolysis involved in protein catabolic process macromolecule catabolic process vesicle-mediated transport organic substance metabolic process late endosome to vacuole transport modification-dependent macromolecule catabolic process late endosome to vacuole transport via multivesicular body sorting pathway proteolysis protein metabolic process endosome transport via multivesicular body sorting pathway organonitrogen compound catabolic process organonitrogen compound metabolic process protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway primary metabolic process protein catabolic process endosomal transport modification-dependent protein catabolic process multivesicular body sorting pathway ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-dependent protein catabolic process macromolecule metabolic process organic substance catabolic process establishment of protein localization to membrane localization within membrane protein localization to membrane protein targeting to membrane	midbody cellular anatomical entity membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome midbody cellular anatomical entity membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle endosome membrane membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane cell periphery plasma membrane protein-containing complex ESCRT complex membrane protein complex ESCRT I complex late endosome membrane late endosome
C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], S [auth T]	Multivesicular body subunit 12A	protein binding binding ubiquitin binding ubiquitin-like protein binding SH3 domain binding protein domain specific binding lipid binding	organelle assembly multivesicular body assembly vesicle organization cellular component organization cellular component biogenesis organelle organization cellular component assembly multivesicular body organization endosome organization cellular process cellular component organization or biogenesis endomembrane system organization organonitrogen compound catabolic process organonitrogen compound metabolic process organelle assembly multivesicular body assembly vesicle organization cellular component organization cellular component biogenesis organelle organization cellular component assembly multivesicular body organization endosome organization cellular process cellular component organization or biogenesis endomembrane system organization organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process virus maturation viral process viral life cycle virion assembly viral budding viral budding via host ESCRT complex cellular response to stimulus regulation of ERBB signaling pathway regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway cell communication regulation of epidermal growth factor receptor signaling pathway regulation of response to stimulus ERBB signaling pathway regulation of cell communication epidermal growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway membrane organization membrane fission cellular catabolic process macroautophagy cellular metabolic process autophagy process utilizing autophagic mechanism protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of protein localization to vacuole vesicle-mediated transport localization late endosome to vacuole transport late endosome to vacuole transport via multivesicular body sorting pathway cellular macromolecule localization establishment of localization in cell endosome transport via multivesicular body sorting pathway organic substance transport protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein localization to vacuole intracellular transport establishment of localization endosomal transport establishment of protein localization to organelle protein transport multivesicular body sorting pathway macromolecule localization protein localization to organelle vacuolar transport intracellular protein transport endosome to lysosome transport lysosomal transport endosome to lysosome transport via multivesicular body sorting pathway receptor catabolic process receptor metabolic process	membrane-bounded organelle organelle cellular anatomical entity vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center intracellular anatomical structure membrane-bounded organelle organelle cellular anatomical entity vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol intracellular membrane-bounded organelle endosome membrane protein-containing complex ESCRT complex endosome membrane intracellular vesicle membrane protein complex ESCRT I complex endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle membrane late endosome membrane late endosome nucleus
D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	Vacuolar protein sorting-associated protein 28 homolog	protein binding binding ubiquitin binding ubiquitin-like protein binding protein-containing complex binding	organelle assembly multivesicular body assembly vesicle organization cellular component organization cellular component biogenesis organelle organization cellular component assembly multivesicular body organization endosome organization cellular process cellular component organization or biogenesis endomembrane system organization negative regulation of post-translational protein modification regulation of protein modification process organelle assembly multivesicular body assembly vesicle organization cellular component organization cellular component biogenesis organelle organization cellular component assembly multivesicular body organization endosome organization cellular process cellular component organization or biogenesis endomembrane system organization negative regulation of post-translational protein modification regulation of protein modification process negative regulation of biological process regulation of protein ubiquitination regulation of primary metabolic process organic substance metabolic process protein ubiquitination negative regulation of protein modification process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process organonitrogen compound metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-dependent protein catabolic process organic substance catabolic process positive regulation of protein metabolic process positive regulation of biological process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of protein catabolic process virion assembly viral process viral budding viral budding via host ESCRT complex viral life cycle membrane organization membrane fission cellular catabolic process macroautophagy cellular metabolic process autophagy process utilizing autophagic mechanism protein localization import into cell regulation of localization ubiquitin-dependent endocytosis establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization regulation of protein localization transport positive regulation of establishment of protein localization vesicle-mediated transport positive regulation of protein transport localization positive regulation of endocytosis cellular macromolecule localization regulation of ubiquitin-dependent endocytosis positive regulation of cellular process regulation of endocytosis regulation of transport organic substance transport regulation of establishment of protein localization regulation of protein transport regulation of vesicle-mediated transport establishment of localization establishment of protein localization to organelle positive regulation of transport protein transport regulation of cellular localization macromolecule localization protein localization to organelle positive regulation of ubiquitin-dependent endocytosis positive regulation of protein localization endocytosis establishment of protein localization to vacuole late endosome to vacuole transport late endosome to vacuole transport via multivesicular body sorting pathway establishment of localization in cell endosome transport via multivesicular body sorting pathway protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway protein localization to vacuole intracellular transport endosomal transport multivesicular body sorting pathway vacuolar transport intracellular protein transport	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane endosome membrane protein-containing complex ESCRT complex endosome intracellular vesicle membrane protein complex intracellular membrane-bounded organelle ESCRT I complex endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle membrane late endosome membrane late endosome early endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J]	IPR016135	Ubiquitin-conjugating enzyme/RWD-like	Homologous Superfamily
A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J]	IPR037202	ESCRT assembly domain	Homologous Superfamily
A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J]	IPR017916	Steadiness box (SB) domain	Domain
A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J]	IPR008883	Ubiquitin E2 variant, N-terminal	Domain
B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], N [auth O]	IPR009851	Modifier of rudimentary, Modr	Domain
B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], N [auth O]	IPR029012	Helix hairpin bin domain superfamily	Homologous Superfamily
B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], N [auth O]	IPR037202	ESCRT assembly domain	Homologous Superfamily
C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], S [auth T]	IPR023340	UMA domain	Domain
C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], S [auth T]	IPR023341	MABP domain	Domain
C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], S [auth T]	IPR018798	Multivesicular body subunit 12	Family
C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], S [auth T]	IPR040335	Multivesicular body subunit 12A	Family
D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR007143	Vacuolar protein sorting-associated Vps28	Family
D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR017898	Vacuolar protein sorting-associated, VPS28, N-terminal	Domain
D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR038358	VPS28, N-terminal domain superfamily	Homologous Superfamily
D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR037202	ESCRT assembly domain	Homologous Superfamily
D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR037206	VPS28, C-terminal domain superfamily	Homologous Superfamily
D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	IPR017899	Vacuolar protein sorting-associated, VPS28, C-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], A [auth B], E [auth F], F [auth G], G [auth H], H [auth I], I [auth J]	Pharos: Q99816	breast carcinoma Mammary Neoplasms plasma cell myeloma hereditary breast carcinoma ovarian cancer
B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], B [auth C], J [auth K], K [auth L], L [auth M], M [auth N], N [auth O]	Pharos: Q9H9H4	adrenal cortex carcinoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma atrial fibrillation ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis B-cell chronic lymphocytic leukemia pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], C [auth D], O [auth P], P [auth Q], Q [auth R], R [auth A], S [auth T]	Pharos: Q96EY5	astrocytic tumor malignant ependymoma oligodendroglioma primitive neuroectodermal tumor tuberculosis atypical teratoid rhabdoid tumor malignant glioma ovarian cancer rheumatoid arthritis glioblastoma medulloblastoma pilocytic astrocytoma subependymal giant cell astrocytoma
D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], D [auth E], T [auth U], U [auth V], V [auth W], W [auth X], X [auth Y]	Pharos: Q9UK41	diabetes mellitus plasma cell myeloma osteosarcoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.