Crystal Structure of 426cOD in Complex with VRC01 Fab
External Resource: Annotation
| Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
|---|
| A [auth H] | PF07654 | e6vlwH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
| A [auth H] | PF07686 | e6vlwH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
| B [auth L] | PF07654 | e6vlwL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07654 | ECOD (1.6) |
| B [auth L] | PF07686 | e6vlwL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: PF07686 | ECOD (1.6) |
| C [auth G] | PF00516 | e6vlwG1 | A: a+b two layers | X: Ribosomal protein L31e-like | H: Ribosomal protein L31e/gp120 outer domain (From Topology) | T: Ribosomal protein L31e/gp120 outer domain | F: PF00516 | ECOD (1.6) |
| Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
|---|
| A [auth H] | Fab VRC01, anti-gp120 CD4-binding site (CD4bs) [HIV-1], broadly | H-GAMMA-1 | Homo sapiens (human) | IGHV1-18*01, IGHV1-18*04, IGHJ3*01, IGHJ3*02, IGHJ6*01, IGHJ6*04, IGHG1*03, IGHG1*08, IGHG1*06 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202421-0) |
| B [auth L] | Fab VRC01, anti-gp120 CD4-binding site (CD4bs) [HIV-1], broadly | L-KAPPA | Homo sapiens (human) | IGKV3-20*01, IGKJ1*01, IGKC*01 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-1_KAPPA | IMGT (202421-0) |
| Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
|---|
| B [auth L] | Light Chain | IGKV3 | Kappa | 426cod | SAbDab (2024-05-31) |
Protein Modification Annotation
| Modified Residue(s) |
|---|
| Chain | Residue(s) | Description |
|---|
| A [auth H] | PCA | Parent Component: GLN
RESID: AA0031
PSI-MOD : 2-pyrrolidone-5-carboxylic acid (Gln) MOD:00040 , 2-pyrrolidone-5-carboxylic acid (Glu) MOD:00420 |
