Annotations: 6VK3

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08238	e6vk3A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF08238	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF07915	Glucosidase II beta subunit-like protein (PRKCSH)	Glucosidase II beta subunit-like protein	-	Family
B	PF17880	Yos9 dimerzation domain (Yos9_DD)	Yos9 dimerzation domain	This is the dimerization domain (DD) found in Yos9 proteins in yeast. Structural analysis revealed that this domain contributes to self association of Yos9. The overall fold of the domain can be classified as an alpha-beta-roll architecture, comprisi ...	This is the dimerization domain (DD) found in Yos9 proteins in yeast. Structural analysis revealed that this domain contributes to self association of Yos9. The overall fold of the domain can be classified as an alpha-beta-roll architecture, comprising two alpha-helices and seven beta-strands [1].	Domain
A	PF08238	Sel1 repeat (Sel1)	Sel1 repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Protein OS-9 homolog	oligosaccharide binding binding carbohydrate binding identical protein binding protein binding	cellular response to stimulus response to organic substance catabolic process response to stimulus proteolysis involved in protein catabolic process carbohydrate derivative metabolic process ubiquitin-dependent glycoprotein ERAD pathway macromolecule catabolic process response to glycoprotein ERAD pathway organic substance metabolic process cellular response to stress response to stress proteolysis cellular response to stimulus response to organic substance catabolic process response to stimulus proteolysis involved in protein catabolic process carbohydrate derivative metabolic process ubiquitin-dependent glycoprotein ERAD pathway macromolecule catabolic process response to glycoprotein ERAD pathway organic substance metabolic process cellular response to stress response to stress proteolysis protein metabolic process response to endoplasmic reticulum stress organonitrogen compound catabolic process carbohydrate derivative catabolic process glycoprotein catabolic process organonitrogen compound metabolic process response to organonitrogen compound response to oxygen-containing compound primary metabolic process response to nitrogen compound proteasomal protein catabolic process protein catabolic process glycoprotein metabolic process response to chemical metabolic process cellular process macromolecule metabolic process organic substance catabolic process detection of stimulus detection of unfolded protein response to topologically incorrect protein detection of chemical stimulus response to unfolded protein protein localization protein exit from endoplasmic reticulum cellular localization establishment of protein localization nitrogen compound transport transport localization establishment of localization in cell cellular macromolecule localization endoplasmic reticulum to cytosol transport organic substance transport intracellular transport establishment of localization protein transport retrograde protein transport, ER to cytosol macromolecule localization intracellular protein transport regulation of biological process regulation of cellular process cellular response to topologically incorrect protein signaling biological regulation endoplasmic reticulum unfolded protein response cellular response to unfolded protein cell communication cellular response to chemical stimulus signal transduction cellular response to organic substance	membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane catalytic complex organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle organelle endoplasmic reticulum cytoplasm Hrd1p ubiquitin ligase complex organelle membrane intracellular protein-containing complex membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen luminal surveillance complex Hrd1p ubiquitin ligase ERAD-L complex
A	Hrd3	-	cellular response to stimulus response to organic substance catabolic process response to stimulus proteolysis involved in protein catabolic process carbohydrate derivative metabolic process ubiquitin-dependent glycoprotein ERAD pathway macromolecule catabolic process response to glycoprotein ERAD pathway organic substance metabolic process cellular response to stress response to stress proteolysis cellular response to stimulus response to organic substance catabolic process response to stimulus proteolysis involved in protein catabolic process carbohydrate derivative metabolic process ubiquitin-dependent glycoprotein ERAD pathway macromolecule catabolic process response to glycoprotein ERAD pathway organic substance metabolic process cellular response to stress response to stress proteolysis protein metabolic process response to endoplasmic reticulum stress organonitrogen compound catabolic process carbohydrate derivative catabolic process glycoprotein catabolic process organonitrogen compound metabolic process response to organonitrogen compound response to oxygen-containing compound primary metabolic process response to nitrogen compound proteasomal protein catabolic process protein catabolic process glycoprotein metabolic process response to chemical metabolic process cellular process macromolecule metabolic process organic substance catabolic process detection of stimulus detection of unfolded protein response to topologically incorrect protein detection of chemical stimulus response to unfolded protein protein localization protein exit from endoplasmic reticulum cellular localization establishment of protein localization nitrogen compound transport transport localization establishment of localization in cell cellular macromolecule localization endoplasmic reticulum to cytosol transport organic substance transport intracellular transport establishment of localization protein transport retrograde protein transport, ER to cytosol macromolecule localization intracellular protein transport negative regulation of post-translational protein modification regulation of protein modification process negative regulation of biological process regulation of protein autoubiquitination regulation of protein ubiquitination regulation of primary metabolic process protein ubiquitination negative regulation of protein modification process regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein ubiquitination negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process negative regulation of protein autoubiquitination negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process protein autoubiquitination negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process macromolecule modification post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal	membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane catalytic complex organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle organelle endoplasmic reticulum cytoplasm Hrd1p ubiquitin ligase complex organelle membrane intracellular protein-containing complex Hrd1p ubiquitin ligase ERAD-M complex membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen luminal surveillance complex Hrd1p ubiquitin ligase ERAD-L complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR012913	Protein OS9-like domain	Domain
B	IPR009011	Mannose-6-phosphate receptor binding domain superfamily	Homologous Superfamily
B	IPR044865	MRH domain	Domain
B	IPR041039	Yos9, dimerzation domain	Domain
B	IPR045149	Protein OS-9-like	Family
A	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A	IPR006597	Sel1-like repeat	Repeat

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Sec, Translocase, and Insertase Proteins	ER-associated protein degradation (ERAD) protein Hrd1 ubiquitin ligase complex

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.