6V4X

Cryo-EM structure of an active human histone pre-mRNA 3'-end processing machinery at 3.2 Angstrom resolution

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth G]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063468	3000419	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Metallo-hydrolase/oxidoreductase	8034424	3001057	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041751	3000419	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	ARM repeat-like	8093027	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041747	3000419	SCOP2B (2022-06-29)
C [auth F]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063452	3000419	SCOP2B (2022-06-29)
D [auth E]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063476	3000419	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth G]	PF01423	e6v4xG1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
H	PF00753,PF11718	e6v4xH2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: PF00753,PF11718	ECOD (1.6)
H	PF10996	e6v4xH1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF10996	ECOD (1.6)
A	PF01423	e6v4xA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
J	PF11935	e6v4xJ1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF11935	ECOD (1.6)
B	PF01423	e6v4xB1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
C [auth F]	PF01423	e6v4xF1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
D [auth E]	PF01423	e6v4xE1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
F [auth C]	PF01423	e6v4xC1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
G [auth D]	PF01423	e6v4xD1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
I	PF07521,PF16661	e6v4xI2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: PF07521,PF16661	ECOD (1.6)
I	PF10996	e6v4xI1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF10996	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth G]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (utative)
A	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (utative)
J	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (utative)
C [auth F]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (utative)
D [auth E]	2.30.30.100	Mainly Beta	Roll	SH3 type barrels.		CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth G]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
H	PF07521	Zn-dependent metallo-hydrolase RNA specificity domain (RMMBL)	Zn-dependent metallo-hydrolase RNA specificity domain	-	Motif
H	PF16661	Metallo-beta-lactamase superfamily domain (Lactamase_B_6)	Metallo-beta-lactamase superfamily domain	This family is part of the metallo-beta-lactamase superfamily.	Domain
H	PF11718	Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term (CPSF73-100_C)	Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term	This is the C-terminal conserved region of the pre-mRNA 3'-end-processing of the polyadenylation factor CPSF-73/CPSF-100 proteins. The exact function of this domain is not known.	Domain
H	PF10996	Beta-Casp domain (Beta-Casp)	Beta-Casp domain	The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease. The active site of this enzyme is located at the interface of these two domains [1].	Domain
A	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
J	PF11935	Symplekin/PTA1 N-terminal (SYMPK_PTA1_N)	Symplekin/PTA1 N-terminal	-	Repeat
B	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
C [auth F]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
D [auth E]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
F [auth C]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
I	PF07521	Zn-dependent metallo-hydrolase RNA specificity domain (RMMBL)	Zn-dependent metallo-hydrolase RNA specificity domain	-	Motif
I	PF16661	Metallo-beta-lactamase superfamily domain (Lactamase_B_6)	Metallo-beta-lactamase superfamily domain	This family is part of the metallo-beta-lactamase superfamily.	Domain
I	PF13299	Cleavage and polyadenylation factor 2 C-terminal (CPSF100_C)	Cleavage and polyadenylation factor 2 C-terminal	-	Family
I	PF10996	Beta-Casp domain (Beta-Casp)	Beta-Casp domain	The beta-CASP domain is found C terminal to the beta-lactamase domain in pre-mRNA 3'-end-processing endonuclease. The active site of this enzyme is located at the interface of these two domains [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
E [auth G]	Small nuclear ribonucleoprotein G	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex P granule cytoplasmic ribonucleoprotein granule germ plasm ribonucleoprotein granule pole plasm intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP prespliceosome U2-type prespliceosome U2-type catalytic step 2 spliceosome
H	Cleavage and polyadenylation specificity factor subunit 3	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity 5'-3' RNA exonuclease activity 5'-3' exonuclease activity RNA exonuclease activity, producing 5'-phosphomonoesters RNA exonuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity 5'-3' RNA exonuclease activity 5'-3' exonuclease activity RNA exonuclease activity, producing 5'-phosphomonoesters RNA exonuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters exonuclease activity RNA binding binding organic cyclic compound binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	cellular biosynthetic process mRNA 3'-end processing cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process mRNA processing mRNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process cellular biosynthetic process mRNA 3'-end processing cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process mRNA processing mRNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process nucleic acid catabolic process RNA 3'-end processing metabolic process cellular process RNA processing macromolecule metabolic process co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway histone mRNA metabolic process mRNA 3'-end processing by stem-loop binding and cleavage regulation of cell cycle phase transition regulation of cellular process positive regulation of biological process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of biological process regulation of cell cycle process biological regulation positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition	protein-containing complex ribonucleoprotein complex membrane-bounded organelle intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex membrane-enclosed lumen intracellular organelle lumen protein-containing complex ribonucleoprotein complex membrane-bounded organelle intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle organelle mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
K [auth Z]	U7 snRNA	-	-	-
A	Small nuclear ribonucleoprotein Sm D3	RNA binding binding organic cyclic compound binding nucleic acid binding histone pre-mRNA DCP binding snRNA binding U7 snRNA binding telomerase RNA binding protein binding enzyme binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation organonitrogen compound metabolic process protein methylation protein alkylation protein metabolic process protein modification process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome catalytic complex telomerase holoenzyme complex U2 snRNP catalytic step 2 spliceosome cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP commitment complex nuclear body U2-type catalytic step 2 spliceosome
J	Symplekin	-	regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding biological regulation negative regulation of molecular function cell adhesion cellular process	intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle nuclear stress granule nucleus intracellular membrane-bounded organelle ribonucleoprotein granule intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle nuclear stress granule nucleus intracellular membrane-bounded organelle ribonucleoprotein granule supramolecular complex cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction cell junction cell periphery plasma membrane membrane protein-containing complex nuclear protein-containing complex mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
L [auth Y]	modified H2a pre-mRNA	-	-	-
B	Small nuclear ribonucleoprotein-associated proteins B and B'	RNA binding binding organic cyclic compound binding nucleic acid binding histone pre-mRNA DCP binding U1 snRNP binding ribonucleoprotein complex binding snRNP binding protein-containing complex binding telomerase RNA binding U2 snRNP binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation organonitrogen compound metabolic process protein methylation protein alkylation protein metabolic process protein modification process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex catalytic complex telomerase holoenzyme complex U2 snRNP catalytic step 2 spliceosome spliceosomal complex histone pre-mRNA 3'end processing complex cytoplasm cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP prespliceosome U2-type prespliceosome U2-type catalytic step 2 spliceosome
C [auth F]	Small nuclear ribonucleoprotein F	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm U2 snRNP catalytic step 2 spliceosome catalytic complex spliceosomal complex cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP U2-type catalytic step 2 spliceosome
D [auth E]	Small nuclear ribonucleoprotein E	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome catalytic complex telomerase holoenzyme complex U2 snRNP catalytic step 2 spliceosome cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP U2-type catalytic step 2 spliceosome
F [auth C]	U7 snRNA-associated Sm-like protein LSm10	RNA binding snRNA binding binding organic cyclic compound binding U7 snRNA binding nucleic acid binding histone pre-mRNA DCP binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing RNA 3'-end processing histone mRNA metabolic process mRNA 3'-end processing mRNA 3'-end processing by stem-loop binding and cleavage mRNA metabolic process nucleic acid catabolic process regulation of cell cycle phase transition regulation of cellular process positive regulation of biological process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of biological process regulation of cell cycle process biological regulation positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition	protein-containing complex intracellular anatomical structure cytoplasmic U snRNP body ribonucleoprotein complex cytoplasm cellular anatomical entity membrane-bounded organelle Cajal body nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle protein-containing complex intracellular anatomical structure cytoplasmic U snRNP body ribonucleoprotein complex cytoplasm cellular anatomical entity membrane-bounded organelle Cajal body nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen nuclear protein-containing complex Sm-like protein family complex U7 snRNP small nuclear ribonucleoprotein complex
G [auth D]	U7 snRNA-associated Sm-like protein LSm11	RNA binding snRNA binding binding organic cyclic compound binding U7 snRNA binding nucleic acid binding	cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA 3'-end processing RNA processing histone mRNA metabolic process mRNA 3'-end processing cellular metabolic process mRNA 3'-end processing by stem-loop binding and cleavage primary metabolic process gene expression cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA 3'-end processing RNA processing histone mRNA metabolic process mRNA 3'-end processing cellular metabolic process mRNA 3'-end processing by stem-loop binding and cleavage primary metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process regulation of biological process regulation of chromatin organization regulation of cellular component organization regulation of cellular process protein-containing complex organization biological regulation protein-DNA complex organization cellular component organization chromatin organization cellular component organization or biogenesis regulation of cell cycle phase transition positive regulation of biological process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle telomerase holoenzyme complex organelle ribonucleoprotein complex histone pre-mRNA 3'end processing complex Sm-like protein family complex membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle telomerase holoenzyme complex organelle ribonucleoprotein complex histone pre-mRNA 3'end processing complex Sm-like protein family complex U7 snRNP small nuclear ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
I	Cleavage and polyadenylation specificity factor subunit 2	RNA binding binding organic cyclic compound binding nucleic acid binding	cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA 3'-end processing RNA processing histone mRNA metabolic process mRNA 3'-end processing cellular metabolic process mRNA 3'-end processing by stem-loop binding and cleavage primary metabolic process gene expression cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA 3'-end processing RNA processing histone mRNA metabolic process mRNA 3'-end processing cellular metabolic process mRNA 3'-end processing by stem-loop binding and cleavage primary metabolic process gene expression macromolecule biosynthetic process mRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process	membrane cellular anatomical entity membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle organelle mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex postsynapse synapse membrane cellular anatomical entity membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle organelle mRNA cleavage and polyadenylation specificity factor complex mRNA cleavage factor complex postsynapse synapse cell junction membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen glutamatergic synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth G]	IPR044641	Sm-like protein Lsm7/SmG	Family
E [auth G]	IPR034098	Small nuclear ribonucleoprotein G	Family
E [auth G]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
E [auth G]	IPR047575	Sm domain	Domain
E [auth G]	IPR010920	LSM domain superfamily	Homologous Superfamily
H	IPR001279	Metallo-beta-lactamase	Domain
H	IPR022712	Beta-Casp domain	Domain
H	IPR021718	Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term	Domain
H	IPR011108	Zn-dependent metallo-hydrolase, RNA specificity domain	Domain
H	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
A	IPR027141	Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3	Family
A	IPR034099	Small nuclear ribonucleoprotein Sm D3	Family
A	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
A	IPR047575	Sm domain	Domain
A	IPR010920	LSM domain superfamily	Homologous Superfamily
J	IPR022075	Symplekin C-terminal	Domain
J	IPR016024	Armadillo-type fold	Homologous Superfamily
J	IPR021850	Symplekin/Pta1	Family
J	IPR032460	Symplekin/Pta1, N-terminal	Domain
J	IPR011989	Armadillo-like helical	Homologous Superfamily
B	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
B	IPR017131	Small ribonucleoprotein associated, SmB/SmN	Family
B	IPR047575	Sm domain	Domain
B	IPR010920	LSM domain superfamily	Homologous Superfamily
C [auth F]	IPR016487	Sm-like protein Lsm6/SmF	Family
C [auth F]	IPR034100	Small nuclear ribonucleoprotein F	Family
C [auth F]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
C [auth F]	IPR047575	Sm domain	Domain
C [auth F]	IPR010920	LSM domain superfamily	Homologous Superfamily
D [auth E]	IPR027078	Small nuclear ribonucleoprotein E	Family
D [auth E]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
D [auth E]	IPR047575	Sm domain	Domain
D [auth E]	IPR010920	LSM domain superfamily	Homologous Superfamily
F [auth C]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
F [auth C]	IPR047575	Sm domain	Domain
F [auth C]	IPR010920	LSM domain superfamily	Homologous Superfamily
G [auth D]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
G [auth D]	IPR047575	Sm domain	Domain
G [auth D]	IPR039267	U7 snRNA-associated Sm-like protein Lsm11	Family
G [auth D]	IPR034109	Sm-like protein Lsm11, middle domain	Domain
G [auth D]	IPR010920	LSM domain superfamily	Homologous Superfamily
I	IPR001279	Metallo-beta-lactamase	Domain
I	IPR022712	Beta-Casp domain	Domain
I	IPR027075	Cleavage and polyadenylation specificity factor subunit 2	Family
I	IPR011108	Zn-dependent metallo-hydrolase, RNA specificity domain	Domain
I	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
I	IPR025069	Cleavage and polyadenylation specificity factor 2, C-terminal	Domain
I	IPR035639	CPSF2, metallo-hydrolase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
E [auth G]	Pharos: P62308	Adenocarcinoma of Lung lung adenocarcinoma
H	Pharos: Q9UKF6	large cell medulloblastoma osteosarcoma subependymal giant cell astrocytoma Malignant neoplasm of breast ovarian cancer medulloblastoma primitive neuroectodermal tumor
A	Pharos: P62318	carcinoma Mammary Neoplasms, Experimental HIV infectious disease sarcomatoid carcinoma acne lymphoplasmacytic lymphoma ovarian cancer undifferentiated carcinoma medulloblastoma plasma cell myeloma dermatomyositis lung cancer mammary neoplasms, animal non-alcoholic fatty liver disease
J	Pharos: Q92797	chronic obstructive pulmonary disease gallbladder disease heart disease Malignant neoplasm of stomach ovarian cancer psoriasis gastric cancer hereditary diffuse gastric adenocarcinoma myocardial infarction pancreatic intraductal papillary-mucinous carcinoma gastric neoplasm malignant colon neoplasm osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
B	Pharos: P14678	cerebrocostomandibular syndrome intellectual disability ovarian cancer atypical teratoid rhabdoid tumor dermatomyositis Disease Progression glioblastoma invasive ductal breast carcinoma malignant glioma medulloblastoma plasma cell myeloma diabetes mellitus gastric cancer hereditary diffuse gastric adenocarcinoma large cell medulloblastoma cerebrocostomandibular syndrome intellectual disability ovarian cancer atypical teratoid rhabdoid tumor dermatomyositis Disease Progression glioblastoma invasive ductal breast carcinoma malignant glioma medulloblastoma plasma cell myeloma diabetes mellitus gastric cancer hereditary diffuse gastric adenocarcinoma large cell medulloblastoma malignant mesothelioma osteosarcoma psoriasis gastric neoplasm lymphoplasmacytic lymphoma
C [auth F]	Pharos: P62306	atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma primitive neuroectodermal tumor chronic obstructive pulmonary disease large cell medulloblastoma malignant glioma squamous cell carcinoma cutaneous melanoma lung cancer medulloblastoma
D [auth E]	Pharos: P62304	hypotrichosis hypotrichosis 11 hypotrichosis simplex breast carcinoma
F [auth C]	Pharos: Q969L4	ovarian cancer pancreatic ductal adenocarcinoma Sjogren syndrome
G [auth D]	Pharos: P83369	Aicardi-Goutieres syndrome gastric cancer hepatocellular carcinoma malignant glioma osteosarcoma pilocytic astrocytoma astrocytic tumor gastric carcinoma large cell medulloblastoma medulloblastoma ovarian cancer pituitary cancer atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma Aicardi-Goutieres syndrome gastric cancer hepatocellular carcinoma malignant glioma osteosarcoma pilocytic astrocytoma astrocytic tumor gastric carcinoma large cell medulloblastoma medulloblastoma ovarian cancer pituitary cancer atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma oligodendroglioma Pick disease
I	Pharos: Q9P2I0	adenoma breast cancer hepatocellular carcinoma malignant glioma myopathy primitive neuroectodermal tumor atypical teratoid rhabdoid tumor exocrine pancreatic carcinoma large cell medulloblastoma malignant pancreatic neoplasm ovarian cancer B-cell acute lymphoblastic leukemia glioblastoma malignant ependymoma medulloblastoma adenoma breast cancer hepatocellular carcinoma malignant glioma myopathy primitive neuroectodermal tumor atypical teratoid rhabdoid tumor exocrine pancreatic carcinoma large cell medulloblastoma malignant pancreatic neoplasm ovarian cancer B-cell acute lymphoblastic leukemia glioblastoma malignant ependymoma medulloblastoma pancreatic ductal adenocarcinoma