Annotations: 6TLH

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF12796	e6tlhA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF12796	ECOD (1.6)
B	PF12796	e6tlhB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ankyrin repeat (From Topology)	T: Ankyrin repeat	F: PF12796	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00023	Ankyrin repeat (Ank)	Ankyrin repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	KN motif and ankyrin repeat domain-containing protein 3	-	regulation of cytoskeleton organization regulation of cellular process regulation of cellular component organization regulation of actin filament-based process negative regulation of biological process regulation of actin filament bundle assembly cellular component biogenesis cellular component organization cellular component assembly actin filament bundle organization actin filament-based process negative regulation of cellular process cellular component organization or biogenesis stress fiber assembly regulation of cytoskeleton organization regulation of cellular process regulation of cellular component organization regulation of actin filament-based process negative regulation of biological process regulation of actin filament bundle assembly cellular component biogenesis cellular component organization cellular component assembly actin filament bundle organization actin filament-based process negative regulation of cellular process cellular component organization or biogenesis stress fiber assembly negative regulation of supramolecular fiber organization regulation of biological process regulation of actin filament organization negative regulation of stress fiber assembly actin cytoskeleton organization actomyosin structure organization negative regulation of cellular component organization negative regulation of cytoskeleton organization biological regulation actin filament organization regulation of cellular component biogenesis negative regulation of actin filament bundle assembly regulation of organelle organization regulation of stress fiber assembly organelle organization negative regulation of organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization cellular process supramolecular fiber organization cytoskeleton organization regulation of cellular component size regulation of protein-containing complex assembly protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization regulation of biological quality negative regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization regulation of actin polymerization or depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of actin filament length regulation of anatomical structure size	intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002110	Ankyrin repeat	Repeat
A, B	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A, B	IPR047184	KN motif and ankyrin repeat domain-containing protein 1-4	Family
A, B	IPR021939	Kank N-terminal motif	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.